PSMB9 Antikörper (C-Term)

Produktnummer ABIN2782473

Produktdetails anti-PSMB9 Antikörper

Target: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Schwein, Kaninchen, Rind (Kuh), Pferd, Meerschweinchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMB9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: RRFTTDAIAL AMSRDGSSGG VIYLVTITAA GVDHRVILGN ELPKFYDE

Homologie: Cow: 92%, Dog: 92%, Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against PSMB9. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human PSMB9

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 219 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PSMB9

Target: PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))

Andere Bezeichnung: PSMB9 (PSMB9 Produkte)

Synonyme: LMP2 antikoerper, ring12 antikoerper, MHC-linked antikoerper, psmb9b antikoerper, lmp2 antikoerper, lmp2b antikoerper, psmb9 antikoerper, Lmp-2 antikoerper, Lmp2 antikoerper, PSMB6i antikoerper, RING12 antikoerper, beta1i antikoerper, psmb9-A antikoerper, macropain antikoerper, prosome antikoerper, wu:fa66f04 antikoerper, wu:fj22d05 antikoerper, zgc:91842 antikoerper, psmb9a antikoerper, proteasome subunit beta 9 antikoerper, LMP2 antikoerper, proteasome subunit beta type-9b antikoerper, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) antikoerper, proteasome subunit beta 9 S homeolog antikoerper, proteasome subunit beta 9a antikoerper, proteasome (prosome, macropain) subunit, beta type, 9a antikoerper, psmb9 antikoerper, PSMB9 antikoerper, psmb9-b antikoerper, Psmb9 antikoerper, psmb9.S antikoerper, psmb9a antikoerper

Hintergrund: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. PSMB9 is a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This subunit is involved in antigen processing to generate class I binding peptides. Expression of PSMB9 is induced by gamma interferon and it replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding different isoforms have been identified, both isoforms are processed to yield the same mature subunit.
Alias Symbols: LMP2, MGC70470, RING12, PSMB6i, beta1i
Protein Interaction Partner: NCOA3, TCEB3, SRC, POLR2L, POLR2K, POLR2J, POLR2I, POLR2H, POLR2G, POLR2F, POLR2E, POLR2D, POLR2C, POLR2B, ESR1, NCOA2, UBC, HCVgp1, PSMA2, PSMB5, PSME2, PSME1, PSMB6, PSMA3, POMP, PSMB8, PSMB7, PSMA7, PSMA1, PSMB9, PSMC5, PSMA4, POLR2A, NCOA1, PSMB10,
Protein Size: 219

Molekulargewicht: 21 kDa

Gen-ID: 5698

NCBI Accession: NM_002800, NP_002791

UniProt: P28065

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA