RNF34 Antikörper (Middle Region)

Produktnummer ABIN2778633

Produktdetails anti-RNF34 Antikörper

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Bindungsspezifität: Middle Region

Reaktivität: Human, Ratte, Rind (Kuh), Hund, Kaninchen, Pferd, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF34 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LVDLVLCHHG LGSEDDMDTS SLNSSRSQTS SFFTRSFFSN YTAPSATMSS

Homologie: Cow: 87%, Dog: 93%, Guinea Pig: 80%, Horse: 93%, Human: 100%, Rabbit: 80%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against RNF34. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RNF34

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 372 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu RNF34

Target: RNF34 (Ring Finger Protein 34 (RNF34))

Andere Bezeichnung: RNF34 (RNF34 Produkte)

Synonyme: CARP-1 antikoerper, CARP1 antikoerper, RFI antikoerper, RIF antikoerper, RIFF antikoerper, hRFI antikoerper, rnf34 antikoerper, AW061037 antikoerper, AW536122 antikoerper, BC004042 antikoerper, C88279 antikoerper, Momo antikoerper, fi35g06 antikoerper, wu:fi35g06 antikoerper, zgc:114043 antikoerper, zgc:171755 antikoerper, ring finger protein 34 antikoerper, E3 ubiquitin-protein ligase RNF34 antikoerper, ring finger protein 34a antikoerper, ring finger protein 34b antikoerper, Residual feed intake antikoerper, RNF34 antikoerper, rnf34 antikoerper, Rnf34 antikoerper, rnf34a antikoerper, rnf34b antikoerper, RFI antikoerper

Hintergrund: RNF34 contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis.The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: FLJ21786, RFI, RIF, RIFF, hRFI, CARP1, CARP-1
Protein Interaction Partner: APPBP2, NOD1, APP, PRKACB, PHF7, TRIM23, UBE2D2, CASP10, CASP8, FZR1, ANAPC2, CDC20, SH3KBP1, PPARGC1A, TP53, UBE2F, UBE2H, DNAJA3,
Protein Size: 372

Molekulargewicht: 42 kDa

Gen-ID: 80196

NCBI Accession: NM_025126, NP_079402

UniProt: Q969K3