UBTF Antikörper (Middle Region)

Produktnummer ABIN2777960

Produktdetails anti-UBTF Antikörper

Target: UBTF (Upstream Binding Transcription Factor, RNA Polymerase I (UBTF))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Pferd, Rind (Kuh), Kaninchen, Schwein, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBTF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LESLPEEEQQ RVLGEEKMLN INKKQATSPA SKKPAQEGGK GGSEKPKRPV

Homologie: Cow: 86%, Guinea Pig: 79%, Horse: 77%, Human: 100%, Mouse: 93%, Pig: 86%, Rabbit: 93%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against UBTF. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human UBTF

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 764 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu UBTF

Target: UBTF (Upstream Binding Transcription Factor, RNA Polymerase I (UBTF))

Andere Bezeichnung: UBTF (UBTF Produkte)

Synonyme: NOR-90 antikoerper, UBF antikoerper, UBF-1 antikoerper, UBF1 antikoerper, A930005G04Rik antikoerper, Tcfubf antikoerper, wu:fj38c10 antikoerper, si:dz180g5.3 antikoerper, ubf antikoerper, Ubtf antikoerper, ubf1 antikoerper, xUBF antikoerper, xUBFbeta2 antikoerper, UBTF antikoerper, nor-90 antikoerper, ubf2 antikoerper, ubtf antikoerper, upstream binding transcription factor, RNA polymerase I antikoerper, upstream binding transcription factor, RNA polymerase I L homeolog antikoerper, upstream binding transcription factor, RNA polymerase I S homeolog antikoerper, UBTF antikoerper, Ubtf antikoerper, ubtf antikoerper, ubtf.L antikoerper, ubtf.S antikoerper

Hintergrund: UBTF is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1. Two UBTF polypeptides, of 94 and 97 kD, exist in the human. UBTF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxesUpstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NOR-90, UBF, UBF1, UBF-1
Protein Interaction Partner: UBC, MDM2, RNF2, Dlg4, ESR1, CDK4, CDK2, CCNE1, CCND1, WDR70, YEATS4, RB1, GRK5, KAT5, SIRT7, POLR1A, MYBBP1A, HDAC1, RUNX2, SUMO2, SMARCA5, MAPK3, MAPK1, SUMO1, PIK3CA, IRS1, TAF1D, tat, MCRS1, TLE1, ACTN4, POLR1E, CHGB, SMURF1, TCOF1, MAD1L1, ZMYM2, SER
Protein Size: 764

Molekulargewicht: 89 kDa

Gen-ID: 7343

NCBI Accession: NM_014233, NP_055048

UniProt: P17480