DMRT1 Antikörper (N-Term)

Produktnummer ABIN2774657

Produktdetails anti-DMRT1 Antikörper

Target: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Bindungsspezifität: N-Term

Reaktivität: Human, Rind (Kuh), Hund, Kaninchen, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMRT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PNDEAFSKPS TPSEAPHAPG VPPQGRAGGF GKASGALVGA ASGSSAGGSS

Kreuzreaktivität: Rind (Kuh), Hund, Human, Schwein

Homologie: Cow: 78%, Dog: 85%, Human: 100%, Pig: 78%, Rabbit: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against DMRT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DMRT1

Anwendungsinformationen

Applikationshinweise: WB Suggested Anti-DMRT1 Antibody Titration: 0.2-1 µg/mL
Positive Control: Human brain.
Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 373 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DMRT1

Target: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Andere Bezeichnung: DMRT1 (DMRT1 Produkte)

Synonyme: DMT1 antikoerper, DMRT1 antikoerper, zgc:136676 antikoerper, dmrt1 antikoerper, dmrt1-alpha antikoerper, dmt1 antikoerper, dmrt1-beta antikoerper, xdmrt1 antikoerper, doublesex and mab-3 related transcription factor 1 antikoerper, doublesex and mab-3 related transcription factor 1 L homeolog antikoerper, doublesex and mab-3 related transcription factor 1 S homeolog antikoerper, DMRT1 antikoerper, Dmrt1 antikoerper, dmrt1 antikoerper, dmrt1.L antikoerper, dmrt1.S antikoerper

Hintergrund: The gene encodes the DMRT1 protein is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. This suggested that DMRT1 may be required for testis development.This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: DMT1
Protein Interaction Partner: Dlg4, TRIM29,
Protein Size: 373

Molekulargewicht: 39 kDa

Gen-ID: 1761

NCBI Accession: NM_021951, NP_068770

UniProt: Q9Y5R6