IRF2 Antikörper

Produktnummer ABIN272167

Produktdetails anti-IRF2 Antikörper

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of IRF-2 protein. (region surrounding Lys129)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/20000-1/40000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu IRF2

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Andere Bezeichnung: IRF2 (IRF2 Produkte)

Synonyme: IRF-2 antikoerper, 9830146E22Rik antikoerper, AI646973 antikoerper, Irf-2 antikoerper, irf2b antikoerper, zgc:103451 antikoerper, irf-2 antikoerper, wu:fc74h04 antikoerper, zgc:76951 antikoerper, interferon regulatory factor 2 antikoerper, interferon regulatory factor 2 L homeolog antikoerper, interferon regulatory factor 2a antikoerper, IRF2 antikoerper, Irf2 antikoerper, irf2 antikoerper, irf2.L antikoerper, irf2a antikoerper

Hintergrund: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gamma p48 (the 48 kDa component of the ISGF-3 complex) and IFN consensus sequence-binding protein (ICSBP).Synonyms: IRF-2, Interferon regulatory factor 2

Molekulargewicht: approx. 47 kDa

Gen-ID: 3660

NCBI Accession: NP_002190

UniProt: P14316