Recognizes CD99, also referred to as E2 antigen, a 32 kDa sialoglycoprotein expressed on all leukocyte lineages. The E2 antigen is the MIC2 gene product and is differentially expressed during T- and B-lymphoid and granulocytic development, with higher densities being expressed during early hematopoietic stages. Mature granulocytes express very little or no CD99. E2 has been shown to be involved in T-cell adhesion processes and is suggested to have a functional role in hematopoietic adhesion pathways. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store undiluted at 4°C.
Dworzak, Fritsch, Buchinger, Fleischer, Printz, Zellner, Schöllhammer, Steiner, Ambros, Gadner: "Flow cytometric assessment of human MIC2 expression in bone marrow, thymus, and peripheral blood." in: Blood, Vol. 83, Issue 2, pp. 415-25, (1994) (PubMed).
Aussel, Bernard, Breittmayer, Pelassy, Zoccola, Bernard: "Monoclonal antibodies directed against the E2 protein (MIC2 gene product) induce exposure of phosphatidylserine at the thymocyte cell surface." in: Biochemistry, Vol. 32, Issue 38, pp. 10096-101, (1993) (PubMed).
Gelin, Aubrit, Phalipon, Raynal, Cole, Kaczorek, Bernard: "The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product." in: The EMBO journal, Vol. 8, Issue 11, pp. 3253-9, (1989) (PubMed).