Reacts with a 110 kDa carbohydrate antigen associated with myelin-associated glycoprotein expressed on 7-35 % of normal peripheral blood lymphocytes including a subset of natural killer cells, a subset of CD8+ peripheral blood suppressor/cytotoxic T cells, and on some neural tissues. CD57 is not expressed on granulocytes, platelets, red blood cells or thymocytes. The function of CD57 is still unclear, however, its expression on T-cell subets occurs in late immune responses. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of peripheral blood lymphocytes analyzed by flow cytometry
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dAngeac, Monier, Pilling, Travaglio-Encinoza, Rème, Salmon: "CD57+ T lymphocytes are derived from CD57- precursors by differentiation occurring in late immune responses." in: European journal of immunology, Vol. 24, Issue 7, pp. 1503-11, (1994) (PubMed).
McGarry, Helfand, Quarles, Roder: "Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1." in: Nature, Vol. 306, Issue 5941, pp. 376-8, (1984) (PubMed).
Abo, Cooper, Balch: "Characterization of HNK-1+ (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 129, Issue 4, pp. 1752-7, (1982) (PubMed).