Interleukin 22 (IL22) (Ala34) Antikörper (Biotin)

Details zu Produkt Nr. ABIN2661327, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL-21
  • IL-22
  • IL-D110
  • IL-TIF
  • ILTIF
  • TIFIL-23
  • TIFa
  • zcyto18
  • IL-22a
  • ILTIFa
  • Iltif
  • RGD1561292
  • interleukin-22
  • interleukin 22
  • IL22
  • il22
  • Il22
Epitop
Ala34
44
13
12
9
8
5
3
3
3
3
1
1
1
1
1
1
Reaktivität
Human
221
121
35
2
2
2
2
1
1
1
1
1
Wirt
Ziege
133
106
50
13
Klonalität (Klon)
Polyklonal ()
Konjugat
Biotin
31
17
14
12
10
10
9
8
8
7
6
6
6
6
6
6
6
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
221
93
62
31
20
13
11
8
6
5
3
3
2
2
2
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Ala34-Isoleucin179 (Accession# NM_020525) was expressed in E. coli.
Klon Poly5161
Isotyp Ig Fraction, IgG
Kreuzreaktivität (Details) In sandwich ELISA, less than 10 % cross-reactivity with recombinant mouse IL-22.
Reinigung The antibody was purified by antigen affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Andere Bezeichnung IL-22 (IL22 Antibody Abstract)
Hintergrund IL-22 is a cytokine structurally related to IL-10. Originally identified as a murine gene induced by IL-9 in T and mast cells, IL-22 was initially designated ILTIF (IL-10-related T cell-derived inducible factor). IL-22 belongs to a family of cytokines with limited homology to IL-10, namely IL-10, IL-19, IL-20, IL-24, IL-26, and the IFN-λs, IL-28A, IL-28B and IL-29. Human IL-22 shares 79 % amino acid identity with murine IL-22 and 25 % identity with human IL-10. IL-22 biological activity is initiated by binding to a cell surface complex composed of IL-22R1 and IL-10R2 receptor chains. Activity is further regulated through interactions with the soluble binding protein, IL-22BP, which shares sequence similarity with an extracellular region of IL-22R1 (sIL-22R1). Both chains of the IL-22R complex belong to the class II CRF. Two types of IL-22 binding receptors have been discovered, a membrane-bound receptor and a soluble receptor, both encoded by different genes. IL-22 is produced by Th17 cells and newly identified Th22 cells. It plays a critical role in mucosal immunity in addition to the deregulated inflammation observed in autoimmune diseases.
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 1 % BSA and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.
Bilder des Herstellers
ELISA image for anti-Interleukin 22 (IL22) (Ala34) antibody (Biotin) (ABIN2661327) anti-Interleukin 22 (IL22) (Ala34) antibody (Biotin)
Allgemeine Veröffentlichungen Trifari, Kaplan, Tran, Crellin, Spits: "Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells." in: Nature immunology, Vol. 10, Issue 8, pp. 864-71, 2009 (PubMed).

Gu, Yang, Ouyang, Liu, Li, Yang, Bromberg, Chen, Mayer, Unkeless, Xiong: "Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells." in: European journal of immunology, Vol. 38, Issue 7, pp. 1807-13, 2008 (PubMed).

Pène, Chevalier, Preisser, Vénéreau, Guilleux, Ghannam, Molès, Danger, Ravon, Lesaux, Yssel, Gascan: "Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 11, pp. 7423-30, 2008 (PubMed).

Kebir, Kreymborg, Ifergan, Dodelet-Devillers, Cayrol, Bernard, Giuliani, Arbour, Becher, Prat: "Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation." in: Nature medicine, Vol. 13, Issue 10, pp. 1173-5, 2007 (PubMed).

Chung, Yang, Chang, Ma, Tian, Dong: "Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes." in: Cell research, Vol. 16, Issue 11, pp. 902-7, 2006 (PubMed).

Nagalakshmi, Rascle, Zurawski, Menon, de Waal Malefyt: "Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells." in: International immunopharmacology, Vol. 4, Issue 5, pp. 679-91, 2004 (PubMed).

Kotenko, Izotova, Mirochnitchenko, Esterova, Dickensheets, Donnelly, Pestka: "Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 12, pp. 7096-103, 2001 (PubMed).

Dumoutier, Louahed, Renauld: "Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1814-9, 2000 (PubMed).

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