Stargazin Antikörper

Produktnummer ABIN265040

Produktdetails anti-Stargazin Antikörper

Target: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Stargazin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody reacts to CACNG2.

Aufreinigung: Purified

Immunogen: Synthetic peptide derived from the rat calcium channel gamma2 subunit conjugated to KLH

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu Stargazin

Target: Stargazin (CACNG2) (Calcium Channel, Voltage-Dependent, gamma Subunit 2 (CACNG2))

Andere Bezeichnung: CACNG2 (CACNG2 Produkte)

Synonyme: cacng2 antikoerper, zgc:64200 antikoerper, CACNG2 antikoerper, stargazin antikoerper, AW060990 antikoerper, B230105C07Rik antikoerper, B930041E13Rik antikoerper, stargazer antikoerper, stg antikoerper, wag antikoerper, waggler antikoerper, Ipr328 antikoerper, MRD10 antikoerper, calcium voltage-gated channel auxiliary subunit gamma 2 antikoerper, calcium channel, voltage-dependent, gamma subunit 2a antikoerper, calcium channel, voltage-dependent, gamma subunit 2 antikoerper, CACNG2 antikoerper, cacng2a antikoerper, cacng2 antikoerper, Cacng2 antikoerper

Hintergrund: Voltage-dependent calcium channels (VDCCs) are large (>400 kDa) heteromers which contain, minimally, three core subunits alpha1, alpha2/delta, beta in a 1:1:1 stoichiometry. Expression of VDCC gene products in Xenopus oocytes, or transfected cells shows that the alpha1 subunits contain the ion channel pore while the auxiliary alpha2/delta and beta subunits confer optimal cell surface expression and channel kinetics1. Until recently, the only exception to the above paradigm was the skeletal muscle VDCC, which, in addition to the alpha1, alpha2/delta, beta core motif, also has an additional tightly associated integral membrane glycoprotein subunit termed gamma 1. Upon co-expression with the alpha1.1, alpha2/delta1, beta1a subunits of the skeletal muscle VDCC, gamma subunits alter the peak currents, and the kinetics of channel activation and inactivation with the overall effect being a normalisation of currents to those resembling the endogenous channel2. Together, these results suggest that gamma subunits modulate skeletal muscle VDCCs by stabilising their conformation. The gamma 2 subunits, or stargazin, the product of a gene mutated in the stargazer mouse, is a homolog of the gamma 1 channel and is selectively expressed in the brain. It is considered to be a putative neuronal Ca2+ channel subtype mainly based on its homology to the gamma 1.Synonyms: Neuronal voltage-gated calcium channel gamma-2 subunit, TARP gamma-2, Transmembrane AMPAR regulatory protein gamma-2, Voltage-dependent calcium channel gamma-2 subunit

Gen-ID: 10369

NCBI Accession: NP_006069

UniProt: Q9Y698

Pathways: Skeletal Muscle Fiber Development