PTGES3 Antikörper

Produktnummer ABIN263974

Produktdetails anti-PTGES3 Antikörper

Target: PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))

Reaktivität: Human, Maus, Meerschweinchen, Kaninchen, Huhn, Saccharomyces cerevisiae

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PTGES3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects ~23 kDa p23.

Produktmerkmale: Synonyms: Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase,Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23

Aufreinigung: Protein G Affinity Chromatography

Immunogen: Recombinant Human full length p23 protein

Klon: JJ6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western blot (1: 2000). Immunprecipitation. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS in 50 % Glycerol, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu PTGES3

Target: PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))

Andere Bezeichnung: PTGES3 / TEBP (PTGES3 Produkte)

Synonyme: P23 antikoerper, TEBP antikoerper, cPGES antikoerper, PTGES3 antikoerper, 5730442A20Rik antikoerper, Ptges antikoerper, Tebp antikoerper, p23 antikoerper, sid3177 antikoerper, RGD1561913 antikoerper, CPGES antikoerper, cPGES-1 antikoerper, ptges3 antikoerper, wu:fb98d06 antikoerper, zgc:65804 antikoerper, zgc:77131 antikoerper, tebp antikoerper, wu:fb50a04 antikoerper, zgc:86751 antikoerper, prostaglandin E synthase 3 antikoerper, prostaglandin E synthase 3 (cytosolic) pseudogene antikoerper, prostaglandin E synthase 3a (cytosolic) antikoerper, prostaglandin E synthase 3 L homeolog antikoerper, prostaglandin E synthase 3b (cytosolic) antikoerper, PTGES3 antikoerper, LOC743066 antikoerper, Ptges3 antikoerper, ptges3a antikoerper, ptges3.L antikoerper, ptges3b antikoerper

Hintergrund: P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated hsp90 binding of client proteins (8). Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.Synonyms: Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, P23, Progesterone receptor complex p23, Prostaglandin E synthase 3, Telomerase-binding protein p23, cPGES

Gen-ID: 10728

UniProt: Q15185

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cellular Glucan Metabolic Process