This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RBCK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RBCK1.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Gustafsson, Zhao, Gustafsson, Dahlman-Wright: "RBCK1 drives breast cancer cell proliferation by promoting transcription of estrogen receptor alpha and cyclin B1." in: Cancer research, Vol. 70, Issue 3, pp. 1265-74, (2010) (PubMed).
Yoshimoto, Tatematsu, Okajima, Tanizawa, Kuroda: "Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1." in: The FEBS journal, Vol. 276, Issue 21, pp. 6375-85, (2009) (PubMed).
Tokunaga, Sakata, Saeki, Satomi, Kirisako, Kamei, Nakagawa, Kato, Murata, Yamaoka, Yamamoto, Akira, Takao, Tanaka, Iwai: "Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation." in: Nature cell biology, Vol. 11, Issue 2, pp. 123-32, (2009) (PubMed).
Target
RBCK1
(RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq].