DCLK2 Antikörper (N-Term)

Produktnummer ABIN1881253

Produktdetails anti-DCLK2 Antikörper

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Bindungsspezifität: AA 167-196, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCLK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DCLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human DCLK2.

Klon: RB41922

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DCLK2 Antikörper (ABIN1881253)

Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).

Kerjan, Koizumi, Han, Dubé, Djakovic, Patrick, Baram, Heinemann, Gleeson: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).

Gorelik, Sapir, Reiner: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." in: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).

Details zu DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Andere Bezeichnung: DCLK2 (DCLK2 Produkte)

Synonyme: CL2 antikoerper, CLICK-II antikoerper, CLICK2 antikoerper, CLIK2 antikoerper, DCAMKL2 antikoerper, DCDC3 antikoerper, DCDC3B antikoerper, DCK2 antikoerper, 6330415M09Rik antikoerper, AU044875 antikoerper, Click-II antikoerper, Dcamkl2 antikoerper, DCLK2 antikoerper, cb572 antikoerper, dclk antikoerper, sb:cb572 antikoerper, si:dkey-180n16.1 antikoerper, Dck2 antikoerper, RGD1308384 antikoerper, doublecortin like kinase 2 antikoerper, doublecortin-like kinase 2 antikoerper, doublecortin-like kinase 2a antikoerper, DCLK2 antikoerper, Dclk2 antikoerper, dclk2a antikoerper

Hintergrund: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Molekulargewicht: 83606

NCBI Accession: NP_001035350, NP_001035351

UniProt: Q8N568