CHRNB2 Antikörper (Middle Region)
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- Target Alle CHRNB2 Antikörper anzeigen
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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Bindungsspezifität
- Middle Region
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Reaktivität
- Human, Maus, Ratte, Hund, Rind (Kuh), Schwein, Meerschweinchen, Saccharomyces cerevisiae
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CHRNB2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- KIEVKHFPFD QQNCTMKFRS WTYDRTEIDL VLKSEVASLD DFTPSGEWDI
- Homologie
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 93%, Pig: 100%, Rat: 93%, Yeast: 77%
- Produktmerkmale
- This is a rabbit polyclonal antibody against CHRNB2. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Protein A purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human CHRNB2
- Top Product
- Discover our top product CHRNB2 Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 502 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
- Andere Bezeichnung
- CHRNB2 (CHRNB2 Produkte)
- Synonyme
- EFNL3 antikoerper, nAChRB2 antikoerper, NACHRB2 antikoerper, Acrb-2 antikoerper, Acrb2 antikoerper, C030030P04Rik antikoerper, [b]2-nAchR antikoerper, cholinergic receptor nicotinic beta 2 subunit antikoerper, cholinergic receptor nicotinic beta 2 subunit S homeolog antikoerper, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) antikoerper, CHRNB2 antikoerper, chrnb2.S antikoerper, Chrnb2 antikoerper
- Hintergrund
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CRELD2, CHRNA4, CHRNA2,
Protein Size: 502 - Molekulargewicht
- 57 kDa
- Gen-ID
- 1141
- NCBI Accession
- NM_000748, NP_000739
- UniProt
- P17787
- Pathways
- Sensory Perception of Sound, Feeding Behaviour
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