T-Bet Antikörper (C-Term)

Produktnummer ABIN183466

Produktdetails anti-T-Bet Antikörper

Target: T-Bet

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Schwein, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser T-Bet Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MDPGLGSSEE QGSSPSLWPE VTSLQPESSD SGLGEGDTKR RRISPYPSSG

Homologie: Cow: 86%, Dog: 86%, Human: 93%, Mouse: 93%, Pig: 93%, Rabbit: 93%, Rat: 93%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against TBX21. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of mouse TBX21

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 530 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu T-Bet

Target: T-Bet

Andere Bezeichnung: TBX21 (T-Bet Produkte)

Synonyme: T-PET antikoerper, T-bet antikoerper, TBET antikoerper, TBLYM antikoerper, TBT1 antikoerper, Tbet antikoerper, Tblym antikoerper, T-box 21 antikoerper, TBX21 antikoerper, Tbx21 antikoerper

Hintergrund: TBX21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. It is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.
Alias Symbols: TBT1, Tbet, Tblym
Protein Interaction Partner: Bcl6, Smarca4, Tlx3, Tead4, Pax9, Gsc, Gata3, Dlx1, Alx4, Rbpj, Stat1, Ifng, Tec, Itk, Txk,
Protein Size: 530

Molekulargewicht: 58 kDa

Gen-ID: 57765

NCBI Accession: NM_019507, NP_062380

UniProt: Q9JKD8