TNFRSF1B Antikörper

Produktnummer ABIN180971

Der Maus Monoklonal anti-TNFRSF1B Antikörper wird verwendet zum Nachweis von TNFRSF1B in Proben von Human. Er wurde validiert für WB, Func, IHC (fro) und EIA.

Kurzübersicht für TNFRSF1B Antikörper (ABIN180971)

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFRSF1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: 31-01-20

Produktdetails anti-TNFRSF1B Antikörper

Produktmerkmale: Synonyms: Tumor necrosis factor receptor 2, p80 TNF-alpha receptor, TNFRSF1B, TNFBR, TNF-R2, Tumornecrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II

Aufreinigung: Affinity Chromatography on Protein G

Immunogen: R-DNA

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Western Blot: 1.0 μg/mL - 2.0 μg/mL. Immunohistochemistry on frozen sections: 15 μg/mL - 25 μg/mL. ELISA: Using the concentrations stated above the detection limits are: ELISA - 5 ng/wellBLOT - 10 ng/lane (reducing conditions). Functional Assays: This antibody neutralises the biological effect of rhTNF RII,but not rhTNF RI.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing without preservatives or stabilizers

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu TNFRSF1B

Target: TNFRSF1B (Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B))

Andere Bezeichnung: CD120b / TNFR2

Hintergrund: Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are membrane glycoproteins and they are from the family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.Synonyms: TNF-R2, TNFBR, TNFRSF1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II, p80 TNF-alpha receptor

UniProt: P20333

Pathways: NF-kappaB Signalweg, Apoptose, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Ubiquitin Proteasome Pathway