APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-38)

Details for Product anti-APP Antibody No. ABIN1449275, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Epitop
AA 18-38
107
107
72
39
37
32
31
19
17
15
15
14
14
13
12
10
9
7
7
7
7
7
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
944
388
368
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Maus
658
262
52
7
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser APP Antikörper ist unkonjugiert
51
43
41
17
15
14
14
14
13
13
13
13
13
13
13
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
672
403
297
165
159
122
90
57
40
35
17
15
15
10
8
3
3
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Synthetic peptide corresponding to APP695 (18-38 aa)
Sequenz LEVPTDGNAG LLAEPQIAMF C
Klon 3-00E-009
Isotyp IgG1
Kreuzreaktivität (Details) Species reactivity (tested):Human, Mouse
Reinigung Protein A agarose
Andere Bezeichnung Amyloid beta A4 Protein / APP (APP Antibody Abstract)
Hintergrund Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gen-ID 351
NCBI Accession NP_000475
UniProt P05067
Forschungsgebiet Neurology, Alzheimer's Disease
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Restore with 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Bilder des Herstellers
Western Blotting (WB) image for anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody (ABIN1449275) anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody
Allgemeine Veröffentlichungen Gylys, Fein, Yang, Wiley, Miller, Cole: "Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence." in: The American journal of pathology, Vol. 165, Issue 5, pp. 1809-17, 2004 (PubMed).

Golde, Estus, Younkin, Selkoe, Younkin: "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives." in: Science (New York, N.Y.), Vol. 255, Issue 5045, pp. 728-30, 1992 (PubMed).

Kang, Lemaire, Unterbeck, Salbaum, Masters, Grzeschik, Multhaup, Beyreuther, Müller-Hill: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).

Haben Sie etwas anderes gesucht?