APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-38)

Details for Product anti-APP Antibody No. ABIN1449275, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Alternativen
anti-Human APP Antikörper für Immunofluorescence (fixed cells)
Epitop
AA 18-38
101
95
68
37
30
25
24
19
17
16
15
15
14
14
12
10
7
7
7
7
6
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus
876
365
351
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Maus
631
229
46
7
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser APP Antikörper ist unkonjugiert
49
39
39
16
14
13
13
13
13
12
12
12
12
12
12
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
623
366
273
158
149
121
83
56
42
34
18
14
10
9
8
3
2
2
1
1
1
1
Optionen
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Immunogen Synthetic peptide corresponding to APP695 (18-38 aa)
Sequenz LEVPTDGNAG LLAEPQIAMF C
Klon 3-00E-009
Isotyp IgG1
Kreuzreaktivität (Details) Species reactivity (tested):Human, Mouse
Reinigung Protein A agarose
Andere Bezeichnung Amyloid beta A4 Protein / APP (APP Antibody Abstract)
Hintergrund Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gen-ID 351
NCBI Accession NP_000475
UniProt P05067
Forschungsgebiet Neurology, Alzheimer's Disease
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Restore with 100 μL of distilled water.
Buffer PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Bilder des Herstellers
Western Blotting (WB) image for anti-APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-38) (ABIN1449275) anti-Amyloid beta (A4) Precursor Protein (APP) (AA 18-38) antibody
Allgemeine Veröffentlichungen Gylys, Fein, Yang, Wiley, Miller, Cole: "Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence." in: The American journal of pathology, Vol. 165, Issue 5, pp. 1809-17, 2004 (PubMed).

Golde, Estus, Younkin, Selkoe, Younkin: "Processing of the amyloid protein precursor to potentially amyloidogenic derivatives." in: Science (New York, N.Y.), Vol. 255, Issue 5045, pp. 728-30, 1992 (PubMed).

Kang, Lemaire, Unterbeck, Salbaum, Masters, Grzeschik, Multhaup, Beyreuther, Müller-Hill: "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor." in: Nature, Vol. 325, Issue 6106, pp. 733-6, 1987 (PubMed).