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Myosin VI Antikörper (AA 1101-1294) (AbBy Fluor® 350)

MYO6 Reaktivität: Maus, Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal AbBy Fluor® 350
Produktnummer ABIN1390239
  • Target Alle Myosin VI (MYO6) Antikörper anzeigen
    Myosin VI (MYO6)
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 7
    • 6
    • 4
    • 1
    • 1
    • 1
    AA 1101-1294
    Reaktivität
    • 30
    • 25
    • 25
    • 1
    • 1
    Maus, Ratte
    Wirt
    • 43
    • 1
    Kaninchen
    Klonalität
    • 43
    • 1
    Polyklonal
    Konjugat
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Myosin VI Antikörper ist konjugiert mit AbBy Fluor® 350
    Applikation
    • 23
    • 20
    • 17
    • 13
    • 12
    • 12
    • 8
    • 6
    • 3
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Myosin VI
    Isotyp
    IgG
    Top Product
    Discover our top product MYO6 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Myosin VI (MYO6)
    Andere Bezeichnung
    MYO6/Myosin VI (MYO6 Produkte)
    Synonyme
    95F antikoerper, 95F MHC antikoerper, CG5695 antikoerper, Dm 95F antikoerper, Dm95F antikoerper, Dmel\\CG5695 antikoerper, Dro95F antikoerper, JAG antikoerper, Jaguar antikoerper, Jar antikoerper, M6 antikoerper, MHC95F antikoerper, MYOVI antikoerper, Mhc95F antikoerper, MyoVI antikoerper, Myosin VI antikoerper, jag antikoerper, ms(3)06746 antikoerper, myosins VI antikoerper, DFNA22 antikoerper, DFNB37 antikoerper, BC029719 antikoerper, Tlc antikoerper, sv antikoerper, RGD1560646 antikoerper, CMY6 antikoerper, jaguar antikoerper, myosin VI antikoerper, jar antikoerper, LOC373230 antikoerper, MYO6 antikoerper, myo6 antikoerper, Myo6 antikoerper
    Hintergrund

    Synonyms: Deafness autosomal recessive 37, DFNA 22, DFNA22, DFNB 37, DFNB37, KIAA0389, MYO 6, Myo6, MYO6_HUMAN, Myosin 6, Myosin VI, Myosin-VI, Myosin6, MyosinVI, Unconventional myosin-6.

    Background: Myosin VI a molecular motor involved in intracellular vesicle and organelle transport, is the only Myosin motor that binds to the pointed end of Actin. This unique Myosin has only one light chain in the lever-arm domain and has highly irregular stepping with a wide range of step sizes, unlike that of other characterized Myosins. It associates with Clathrin-coated vesicles and disabled 2, indicating a role for Myosin VI in endocytosis. Mouse Myosin VI is expressed within the sensory hair cells of the cochlea. Human Myosin VI is mapped to the centromeric region of chromosome 6, a region that shows syntenic homology with the corresponding mouse chromosome 9 region, where the Snell?s Waltzer mutation is located. The behavioral effects of the mouse Snell?s Waltzer mutation are lack of responsiveness to sound, hyperactivity, head tossing and circling, due to the disorganization and fusing of stereocilia bundles within the inner ear. Defects of Myosin VI cause autosomal dominant nonsyndromic sensori-neural deafness in humans. Human Myosin VI is expressed in fetal cochlea and brain, as well as in adult brain.

    Pathways
    Sensory Perception of Sound, Dicarboxylic Acid Transport, Asymmetric Protein Localization
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