Interleukin 33 Antikörper (IL33)

Details for Product anti-IL33 Antibody No. ABIN1169169, Anbieter: Anmelden zum Anzeigen
Antigen
  • IL33
  • C9orf26
  • DVS27
  • IL1F11
  • NF-HEV
  • NFEHEV
  • RP11-575C20.2
  • 9230117N10Rik
  • Il-33
  • Il1f11
  • RGD1311155
  • interleukin 33
  • IL33
  • Il33
Reaktivität
Maus
292
106
48
8
4
3
2
2
Wirt
Maus
191
132
24
23
4
3
2
1
1
Antikörpertyp
Recombinant Antibody
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Interleukin 33 Antikörper ist unkonjugiert
36
19
14
14
12
7
5
5
5
4
4
3
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Applikation
ELISA, Functional Studies (Func)
282
215
90
61
45
24
21
21
16
14
13
10
7
5
5
4
4
3
3
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Mouse recombinant IL-33.
Klon Bondy-1-1
Isotyp IgG2b
Spezifität Recognizes mouse IL-33.
Kreuzreaktivität Maus
Reinigung Purified from HEK 293 cell culture supernatant.
Reinheit >95 % (SDS-PAGE)
Endotoxin-Niveau <0.01EU/μg purified protein (LAL test, Lonza).
Andere Bezeichnung IL-33 (IL33 Antibody Abstract)
Hintergrund Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL-33 binds to and signals through ST2 (IL-1R1) and its stimulation recruits MYD88, IRAK, IRAK4 and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14) and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases and sepsis. Anti-IL-33, mAb (recombinant) (blocking) (Bondy-1-1) is an antibody developed by antibody phage display technology using a human naive antibody gene library. These libraries consist of scFv (single chain fragment variable) composed of VH (variable domain of the human immunoglobulin heavy chain) and VL (variable domain of the human immunoglobulin light chain) connected by a polypeptide linker. The antibody fragments are displayed on the surface of filamentous bacteriophage (M13). This scFv was selected by affinity selection on antigen in a process termed panning. Multiple rounds of panning are performed to enrich for antigen-specific scFv-phage. Monoclonal antibodies are subsequently identified by screening after each round of selection. The selected monoclonal scFv is cloned into an appropriate vector containing a Fc portion of interest and then produced in mammalian cells to generate an IgG like scFv-Fc fusion protein.
UniProt Q8BVZ5
Pathways Production of Molecular Mediator of Immune Response
Applikationshinweise Optimal working dilution should be determined by the investigator.
Kommentare

anti-IL-33 (mouse), monoclonal antibody (recombinant) (Bondy-1-1) is composed of human variable regions (VH and VL) (lambda-chain) of immunoglobulin fused to the mouse lgG2b Fc domain.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer In PBS containing 10 % glycerol
Konservierungsmittel Without preservative
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Haltbarkeit 12 months
Bilder des Herstellers
ELISA image for anti-Interleukin 33 (IL33) antibody (ABIN1169169) Binding of IL-33 (mouse) to ST2/IL-1RAcP is inhibited by IL-33 (mouse), mAb (rec.) (b...
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