anti-PRKAA1 (PRKAA1) Antikörper

Bezeichnung:
anti-Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit Antikörper (PRKAA1)
Auf www.antikoerper-online.de finden Sie aktuell 318 Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Antikörper von 29 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PRKAA1 Kits (20) und PRKAA1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 355 PRKAA1 Produkte verfügbar.
Synonyme:
AI194361, AI450832, AL024255, AMPK, AMPK1, AMPKa1, AMPKalpha1, C130083N04Rik, cb116, im:7154392, PRKAA1, sb:cb130, wu:fa94c10
Alle Antikörper anzeigen Gen GeneID UniProt
PRKAA1 108080  
PRKAA1 5562 Q13131
PRKAA1 65248 P54645

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Meistgesuchte Reaktivitäten zu anti-PRKAA1 (PRKAA1) Antikörper

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anti-Mouse (Murine) PRKAA1 Antikörper:

anti-Human PRKAA1 Antikörper:

anti-Rat (Rattus) PRKAA1 Antikörper:

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Am meisten referenzierte anti-PRKAA1 Antikörper

  1. Cow (Bovine) Polyclonal PRKAA1 Primary Antibody für ICC, IF - ABIN151706 : Zang, Zuccollo, Hou, Nagata, Walsh, Herscovitz, Brecher, Ruderman, Cohen: AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. in The Journal of biological chemistry 2004 (PubMed)
    Zeige alle 12 Referenzen für 151706

  2. Human Monoclonal PRKAA1 Primary Antibody für IF, WB - ABIN393792 : Jassim, Fernø, Theisen, Haberhausen, Christoforou, Håvik, Gebhardt, Remschmidt, Mehler-Wex, Hebebrand, Lehellard, Steen: Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. in Pharmacopsychiatry 2011 (PubMed)
    Zeige alle 5 Referenzen für 393792

  3. Human Polyclonal PRKAA1 Primary Antibody für IHC (p), WB - ABIN359481 : Pang, Xiong, Li, Qiu, Jin, Shen, Li: Conserved alpha-helix acts as autoinhibitory sequence in AMP-activated protein kinase alpha subunits. in The Journal of biological chemistry 2007 (PubMed)
    Zeige alle 3 Referenzen für 359481

  4. Human Monoclonal PRKAA1 Primary Antibody für ELISA, FACS - ABIN4280435 : Xiao, Kwong, Daemen, Belvin, Liang, Hatzivassiliou, OBrien: Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable. in PLoS ONE 2016 (PubMed)
    Zeige alle 3 Referenzen für 4280435

  5. Human Polyclonal PRKAA1 Primary Antibody für IF (p), IHC (p) - ABIN737886 : Fu, Zhu, Dodson, Du: AMP-activated protein kinase stimulates Warburg-like glycolysis and activation of satellite cells during muscle regeneration. in The Journal of biological chemistry 2015 (PubMed)
    Zeige alle 3 Referenzen für 737886

  6. Human Polyclonal PRKAA1 Primary Antibody für EIA, WB - ABIN359393 : Zhang, Ye, Wu, Ren, Zhao, Zhao, Fu, Shen, Fan, Lu, Zhong, Xu, Han, Zhang, Tao, Huang, Zhou, Hu, Gu, Chen, Chen: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. in Genome research 2000 (PubMed)
    Zeige alle 2 Referenzen für 359393

  7. Cow (Bovine) Polyclonal PRKAA1 Primary Antibody für WB - ABIN2785500 : Hasumi, Baba, Hong, Hasumi, Huang, Yao, Valera, Linehan, Schmidt: Identification and characterization of a novel folliculin-interacting protein FNIP2. in Gene 2008 (PubMed)

  8. Human Polyclonal PRKAA1 Primary Antibody für FACS, IHC (p) - ABIN652306 : Puissant, Robert, Fenouille, Luciano, Cassuto, Raynaud, Auberger: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. in Cancer research 2010 (PubMed)

Weitere Antikörper gegen PRKAA1 Interaktionspartner

Mouse (Murine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. The metformin-rescued P23H rhodopsin (zeige RHO Antikörper) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (zeige RHO Antikörper) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. Mechanistically, miR (zeige MLXIP Antikörper)-499 directly targets Fnip1 (zeige FNIP1 Antikörper), an AMP-activated protein kinase (AMPK (zeige PRKAA2 Antikörper))-interacting protein that negatively regulates AMPK, a known activator of PGC-1alpha (zeige PPARGC1A Antikörper). This miR (zeige MLXIP Antikörper)-499/Fnip1 (zeige FNIP1 Antikörper)/AMPK circuit can serve as a mechanism to couple muscle fiber type and mitochondrial function.

  3. dopamine is coupled to AMPK activation, which provides a substantial anti-inflammatory and bioenergetic advantage and reduces the severity of endotoxin-induced acute lung injury.

  4. AMPKalpha1 deficiency suppresses brown adipogenesis in favor of fibrogenesis during brown adipose tissue development.

  5. mitochondrial dysfunction triggers LKB1 (zeige STK11 Antikörper)-mediated AMPK activation, which stimulates Sirt2 (zeige SIRT2 Antikörper) phosphorylation, leading to activation of mTOR (zeige FRAP1 Antikörper)-RAPTOR (zeige RPTOR Antikörper) and Glut1 (zeige SLC2A1 Antikörper)-mediated glucose uptake.

  6. AMPK-dependent metabolic repair mechanisms are important for mitigating lung injury.

  7. these data demonstrated that LKB1 (zeige STK11 Antikörper)/AMPK signaling pathway activation improved the survival of diabetic mice complicated with endotoxemia. Thus, LKB1 (zeige STK11 Antikörper)/AMPK signaling pathway may serve as a potentially useful therapeutic target for severe infection in diabetic patients.

  8. We confirmed that procyanidins suppressed acute hyperglycemia with an oral glucose tolerance test in a dose-dependent manner.procyanidins, especially cinnamtannin A2, significantly ameliorate postprandial hyperglycemia at least in part by promoting GLUT4 (zeige SLC2A4 Antikörper) translocation to the plasma membrane by activating both insulin (zeige INS Antikörper)- and AMPK-signaling pathways.

  9. These findings demonstrate that the AMPK-TBC1D1 (zeige TBC1D1 Antikörper) signaling nexus interacts with the PKB (zeige AKT2 Antikörper)-mTOR (zeige FRAP1 Antikörper) pathway via IGF1 (zeige IGF1 Antikörper) secretion, which consequently controls expression of lipogenic genes in the adipose tissue

  10. AMPKa1 deficiency impairs autophagy-mediated monocyte differentiation and decreases monocyte/macrophage survival

Cow (Bovine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (zeige PRKAA2 Antikörper)).

  2. The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.

  3. Nitrated oleic acid activates AMPK in endothelial cells.

  4. Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Antikörper) involves activation of AMPK.

  5. Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.

  6. the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (zeige NOS3 Antikörper)

Human Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. The metformin-rescued P23H rhodopsin (zeige RHO Antikörper) was still intrinsically unstable and led to increased structural instability of the rod outer segments. These data suggest that improving the traffic of misfolding rhodopsin (zeige RHO Antikörper) mutants is unlikely to be a practical therapy, but also highlights the potential of altering translation through AMPK to improve protein function in other protein misfolding diseases

  2. These results suggest that the LKB1 (zeige STK11 Antikörper)-AMPK-FoxO1 (zeige FOXO1 Antikörper) signaling pathway is a critical mediator of the antioxidant properties of H2, further supporting the idea that H2 acts as a signaling molecule to serve various physiological functions.

  3. this study shows taht AMPK reduces abnormal inflammatory responses and cellular senescence, which implicates as a potential therapeutic target for chronic obstructive pulmonary disease/emphysema

  4. Salusin-beta mediates high glucose-induced endothelial injury via disruption of AMPK signaling pathway.

  5. These findings identify a key mechanism of tolerance to Ras-Raf (zeige RAF1 Antikörper) pathway inhibitors and suggest that blocking either AMPK or autophagy in combination with these targeted inhibitors could increase tumor regression and decrease the likelihood of eventual recurrence.

  6. the Runx2 (zeige RUNX2 Antikörper) knockdown cells displayed activation of AMP-activated protein kinase (AMPKalpha (zeige GRK4 Antikörper)), the sensor of cellular metabolism. Importantly, the Runx2 (zeige RUNX2 Antikörper) knockdown in bone-derived cells resulted in increased sensitivity to both Erk1/2 (zeige MAPK1/3 Antikörper) inhibition and AMPKalpha (zeige GRK4 Antikörper) activation by PD184161 and metformin, respectively, despite increased IGF-1Rbeta and AMPKalpha (zeige GRK4 Antikörper) levels.

  7. Data indicate that siRNA-mediated knockdown of AMP-activated protein kinase (zeige PRKAA2 Antikörper) alpha (zeige PAK1 Antikörper) subunit (zeige POLG Antikörper) AMPKalpha1 inhibited icaritin-induced autophagy activation, but exacerbated colorectal cancer (CRC (zeige CALR Antikörper)) cell death.

  8. Retinoid-related orphan receptor alpha (RORalpha) reduction occurs in gastric cancer leading to the survival of tumor cells, which is attenuated by AMP-activated protein kinase (AMPK (zeige PRKAA2 Antikörper)), therefore, both RORalpha and AMPK are potential targets for the intervention and therapy in gastric carcinoma.

  9. BCLB (zeige BCL2L10 Antikörper) expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC (zeige FAM126A Antikörper) cells through the adenosine monophosphate-activated protein kinase AMPK (zeige GRK4 Antikörper)-mTOR (zeige FRAP1 Antikörper) signaling cascade.

  10. findings show that dengue virus ( DENV) infection activates and requires the central metabolic regulator AMPK for its replication and the induction of lipophagy. This is required for the induction of lipophagy, but not basal autophagy, in DENV-infected cells

Zebrafish Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.

Xenopus laevis Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa (zeige SLC34A1 Antikörper) oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.

  2. NDPK-A (zeige NME1 Antikörper) exists in a functional cellular complex with AMPK (zeige PRKAA2 Antikörper) and CFTR (zeige CFTR Antikörper) in airway epithelia, and NDPK-A (zeige NME1 Antikörper) catalytic function is required for the AMPK (zeige PRKAA2 Antikörper)-dependent regulation of CFTR (zeige CFTR Antikörper)

Pig (Porcine) Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1) Interaktionspartner

  1. Klotho (zeige KL Antikörper) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (zeige GRK4 Antikörper)-RUNX2 (zeige RUNX2 Antikörper) pathway.

  2. AMPK-mTOR (zeige FRAP1 Antikörper)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.

  3. Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (zeige MYLIP Antikörper)-1285 and thus activating AMP-activated protein kinase (AMPK (zeige PRKAA2 Antikörper)).

  4. L-Glutamine (zeige GFPT2 Antikörper) enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.

  5. AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.

  6. AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.

  7. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (zeige MAPK1 Antikörper)/TSC2 (zeige TSC2 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

  8. AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.

  9. AMPK functions to inhibit IGF-I (zeige IGF1 Antikörper)-stimulated PI3K pathway activation through stimulation of IRS-1 (zeige IRS1 Antikörper) serine 794 phosphorylation.

  10. acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation

PRKAA1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternative names and synonyms associated with PRKAA1

  • protein kinase, AMP-activated, alpha 3 catalytic subunit (Prkaa3) Antikörper
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1) Antikörper
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (prkaa1) Antikörper
  • protein kinase, AMP-activated, alpha 1 catalytic subunit (Prkaa1) Antikörper
  • AI194361 Antikörper
  • AI450832 Antikörper
  • AL024255 Antikörper
  • AMPK Antikörper
  • AMPK1 Antikörper
  • AMPKa1 Antikörper
  • AMPKalpha1 Antikörper
  • C130083N04Rik Antikörper
  • cb116 Antikörper
  • im:7154392 Antikörper
  • PRKAA1 Antikörper
  • sb:cb130 Antikörper
  • wu:fa94c10 Antikörper

Bezeichner auf Proteinebene für PRKAA1

protein kinase, AMP-activated, alpha 3 catalytic subunit , protein kinase, AMP-activated, alpha 1 catalytic subunit , 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein , 5'-AMP-activated protein kinase catalytic subunit alpha-1 , AMPK-activated protein kinase alpha-1 subunit , 5'-AMP-activated protein kinase alpha 1 catalytic subunit , 5'-AMP-activated protein kinase, catalytic alpha-1 chain , ACACA kinase , AMP -activate kinase alpha 1 subunit , AMP-activated protein kinase, catalytic, alpha-1 , AMPK alpha 1 , AMPK subunit alpha-1 , HMGCR kinase , acetyl-CoA carboxylase kinase , hydroxymethylglutaryl-CoA reductase kinase , tau-protein kinase PRKAA1 , AMPK alpha-1 chain , AMP-activated protein kinase, alpha 1 catalytic subunit , ampka1 , 5'-AMP-activated protein kinase alpha-1 catalytic subunit , AMPKalpha1 , 63 kDa subunit , AMPK 63 kDa subunit

GENE ID SPEZIES
108080 Mus musculus
100009710 Equus caballus
100034740 Meleagris gallopavo
100145520 Xenopus (Silurana) tropicalis
100294665 Ovis aries
540404 Bos taurus
5562 Homo sapiens
65248 Rattus norvegicus
105787 Mus musculus
100001198 Danio rerio
495290 Xenopus laevis
427185 Gallus gallus
479351 Canis lupus familiaris
100145903 Sus scrofa
100174304 Pongo abelii
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