anti-Human DDX58 Antikörper für Enzyme Immunoassay

Recommended DDX58 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antikörper
  • RIG-I
  • RIGI
  • RLR-1
  • 6430573D20Rik
  • C330021E21
  • RHIV-1
  • RIG-1
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
  • DDX58
  • Ddx58
Epitop
AA 592-622
17
9
6
5
5
4
4
3
3
3
3
3
2
2
1
1
1
1
1
1
Reaktivität
Human
168
90
31
21
17
3
2
Wirt
Kaninchen
116
47
9
6
Klonalität
Polyklonal
Konjugat
Dieser DDX58 Antikörper ist unkonjugiert
12
8
6
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Western Blotting (WB)
131
57
46
40
27
12
11
5
5
4
2
2
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN357195
$ 390.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN357193 EIA WB Rabbit Ig C-Term Anmelden zum Anzeigen Polyclonal 5
1 ABIN5555173 EIA IHC (p) WB Rabbit IgG Anmelden zum Anzeigen Polyclonal

General

Antigen DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) Antikörper
Epitop AA 592-622
(17), (9), (6), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(168), (90), (31), (21), (17), (3), (2)
Wirt Kaninchen
(116), (47), (9), (6)
Klonalität
Polyklonal
Konjugat Dieser DDX58 Antikörper ist unkonjugiert
(12), (8), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Western Blotting (WB)
(131), (57), (46), (40), (27), (12), (11), (5), (5), (4), (2), (2), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DDX58 Antikörper

Target Details DDX58 Anwendungsinformationen Handhabung Referenzen für anti-DDX58 Antikörper (ABIN357195) Bilder
Spezifität This antibody detects Human RIG-I at center.
Reinigung Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Immunogen KLH conjugated synthetic peptide between 592~622 amino acids from the center region of Human RIG-I . Genename: DDX58
Isotyp Ig

Target Details DDX58

Produktdetails anti-DDX58 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-DDX58 Antikörper (ABIN357195) Bilder zurück nach oben
Antigen
Andere Bezeichnung DDX58 (DDX58 Antibody Abstract)
Hintergrund DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.Synonyms: DEAD box protein 58, DKFZp434J1111, DKFZp686N19181, FLJ13599, Probable ATP-dependent RNA helicase DDX58, RIG-1, RIG-I, Retinoic acid-inducible gene 1 protein
Molekulargewicht 106600 Da
Gen-ID 23586, 9606
UniProt O95786
Forschungsgebiet Immunology, Chromatin Binding Proteins, DNA/RNA, Transcription Factors
Pathways Activation of Innate immune Response, Hepatitis C

Anwendungsinformationen

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Handhabung Referenzen für anti-DDX58 Antikörper (ABIN357195) Bilder zurück nach oben
Applikationshinweise ELISA 1: 1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Anwendungsinformationen Referenzen für anti-DDX58 Antikörper (ABIN357195) Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Referenzen für anti-DDX58 Antikörper (ABIN357195)

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Li, Chen, Kato, Gale, Lemon: "Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 16739-47, 2005

Breiman, Grandvaux, Lin, Ottone, Akira, Yoneyama, Fujita, Hiscott, Meurs: "Inhibition of RIG-I-dependent signaling to the interferon pathway during hepatitis C virus expression and restoration of signaling by IKKepsilon." in: Journal of virology, Vol. 79, Issue 7, pp. 3969-78, 2005

Cui, Imaizumi, Yoshida, Borden, Satoh: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, 2004

Imaizumi, Yagihashi, Hatakeyama, Yamashita, Ishikawa, Taima, Yoshida, Inoue, Fujita, Yagihashi, Satoh: "Expression of retinoic acid-inducible gene-I in vascular smooth muscle cells stimulated with interferon-gamma." in: Life sciences, Vol. 75, Issue 10, pp. 1171-80, 2004

Imaizumi, Hatakeyama, Yamashita, Yoshida, Ishikawa, Taima, Satoh, Mori, Wakabayashi: "Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells." in: Endothelium : journal of endothelial cell research, Vol. 11, Issue 3-4, pp. 169-73, 2004

Bilder

Produktdetails anti-DDX58 Antikörper Target Details DDX58 Anwendungsinformationen Handhabung Referenzen für anti-DDX58 Antikörper (ABIN357195) zurück nach oben
Bilder des Herstellers
 image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 592-622) antibody (ABIN357195) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58) (AA 592-622) antibody