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Herrmann, Widmann, Colaianni, Colucci, Zallone, Herrmann: Increased osteoclast activity in the presence of increased homocysteine concentrations. in Clinical chemistry 2005
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Human Cathepsin K ELISA Kit für Sandwich ELISA - ABIN414639
Kim, Woo, Kim, Jang, Hwang, Kwon, Choi, Kim, Cheng, Jin, Kim, Kim, Kim: Biochemical and clinical correlation of intraplaque neovascularization using contrast-enhanced ultrasound of the carotid artery. in Atherosclerosis 2014
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Rat (Rattus) Cathepsin K ELISA Kit für Sandwich ELISA - ABIN416185
Salamanna, Martini, Pagani, Parrilli, Giavaresi, Maltarello, Fini: MRMT-1 rat breast carcinoma cells and models of bone metastases: improvement of an in vitro system to mimic the in vivo condition. in Acta histochemica 2012
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Human Cathepsin K ELISA Kit für Sandwich ELISA - ABIN367083
Boanini, Torricelli, Forte, Pagani, Mihailescu, Ristoscu, Mihailescu, Bigi: Antiresorption implant coatings based on calcium alendronate and octacalcium phosphate deposited by matrix assisted pulsed laser evaporation. in Colloids and surfaces. B, Biointerfaces 2015
CatK inhibition in horses did affect bone marrow nucleated cells other than mature osteoclasts rendering them hypo-responsive to both TLR4 (zeige TLR4 ELISA Kits)- and TLR9 (zeige TLR9 ELISA Kits)-induced inflammation, predicting a proteolytic activity for CatK within the MyD88 (zeige MYD88 ELISA Kits) pathway and/or the following proteolytic events required for the cytokines secretion.
components of the large latent TGFss complex were identified as novel targets of cathepsin K at neutral pH.
Of 160 top compounds tested in enzymatic assays, 28 compounds showed blocking of the collagenase activity of Cathepsin K (CatK) at 100 muM.
Cathepsin K cleavage of SDF-1alpha inhibits its chemotactic activity towards glioblastoma stem-like cells.
Increased cathepsin K expression in skull base chordoma was associated with tumor invasion and reduced progression free survival.
Immunohistochemistry confirmed cathepsin K protein was expressed in lymphangioleiomyomatosis but not control lungs. Cathepsin K gene expression and protein and protease activity were detected in lymphangioleiomyomatosis -associated fibroblasts but not the LAM (zeige TSC1 ELISA Kits) cell line 621-101.
The allosteric site of cathepsin K has been modified by site-directed mutagenesis, and it was shown that it is involved in specific regulation of the collagenolytic activity of cathepsin K.
Cathepsin K and osteocalcin (zeige BGLAP ELISA Kits) plasma levels may be suggested as the significant markers of osteopoenia/osteoporosis. In addition, cathepsin K plasma level can be also a valuable marker of severe Coronary Atherosclerosis and Coronary Artery Calcification .
Six mutations in CTSK were identified in 33 families with pycnodysostosis. The high frequency of pycnodysostosis in Ceara State is the consequence of the high inbreeding in that region.
The above studies not only demonstrated that CTSK was widely expressed in tooth-related cells (including odonto- clasts, periodontal ligament cells, pulp cells and odonto- blasts), but also indicated that CTSK was closely related to the development of tissues in oral and maxillofacial region as well as occurrence and development of many oral diseases.
This mutation (c.480_481insT), (p.L160fsX173) is a novel frameshift mutation. The index case extends the phenotypic spectrum and the list of previously reported mutations in the CTSK gene.
There is an increase in levels of CATK in type 1 Gaucher patients compared to the control group. In the patient group, CATK showed higher levels in patients with bone damage compared to those without it.
The CTSK marker was associated with back fat thickness and lean cuts (P < 0.01), and average daily gain and feed:gain ratio (P < 0.05) estimated breeding values.
The authors showed CTSK upregulation in human lung specimens and elevated serum CTSK levels of patients with tuberculosis, compared with controls.
Down-regulation of cathepsin K in synovium at the initial stage of osteoarthritis significantly accelerated cartilage degeneration.
This study established a possible role of CatK in TLR7 (zeige TLR7 ELISA Kits) proteolytic activation, Treg immunosuppressive activity, and lupus autoimmunity and pathology.
catK deficiency almost completely blunted the increased vascular remodeling response of apoE (zeige APOE ELISA Kits)-/- mice to flow cessation, possibly by correcting hyperlipidemia-associated pro-inflammatory effects on the peripheral immune response
The effects of muscarinic receptor (zeige CHRM5 ELISA Kits) M3 knockout on cathepsin K expression, bone density and biomechanical properties of bone are reported.
Cathepsin K expression is increased in the bone of a diabetic mouse model.
Data suggest Ctsk gene, key gene upregulated during osteoclast differentiation, is transcriptionally activated during cell hypoxia-induced mitochondrial dysfunction/disruption; hnRNPA2 (zeige HNRNPA2B1 ELISA Kits) (heterogeneous ribonucleoprotein (zeige RBP31 ELISA Kits) A2) is coactivator in this process.
cathepsin K knockout attenuates age-related decline in cardiac function via suppressing caspase (zeige CASP3 ELISA Kits)-dependent and caspase (zeige CASP3 ELISA Kits)-independent apoptosis
Data (including data from studies in knockout/transgenic mice) suggest that Ctsk is involved in inflammatory response and bone resorption in both rheumatoid arthritis and periodontitis; thus, Ctsk appears to play a role in osteoimmune responses.
In a mouse model of post-traumatic osteoarthritis, cathepsin K activity was significantly increased in injured knees relative to uninjured knees.
Gene deletion of cathepsin K in mice accelerated callus size resolution, significantly increased callus mineralized mass, and improved mechanical strength as compared to wild type mice.
synergism between HIV proteins and pro-atherogenic shear stress to increase endothelial cell expression of the powerful protease cathepsin K
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.
, 26-29 kD-proteinase
, 26-29kDa proteinase
, 26-29kd prot
, cathepsin K
, Cathepsin K
, cathepsin O
, cathepsin O1
, cathepsin O2
, cathepsin X
, protein OC-2
, Cat K
, minisatellite 10q detected by probe MMS10
, cathepsin K (pycnodysostosis)
, cathepsin K preproprotein