(Dap22)-ShK
-
- Target
- (Dap22)-Stichodactyla helianthus Neurotoxin (ShK)
- Applikation
- Blocking Reagent (BR)
- Sequenz
- AA sequence: Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys- Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser -Met-Dap-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys -Thr-Cys32-Gly-Thr-Cys35-OH Disulfide bonds: Cys3-Cys35, Cys12-Cys28 and Cys17-Cys32
- Produktmerkmale
- Selective blocker of Kv1.3
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Lagerung
- -20 °C
-
- Target
- (Dap22)-Stichodactyla helianthus Neurotoxin (ShK)
- Hintergrund
- (Dap22)-ShK (ShK Dap22) peptide is a synthetic derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks voltage-gated Kv1.1, Kv1.3, Kv1.4 and Kv1.6 channels at equal subnanomolar concentrations. In (Dap22)-ShK, lysine22 has been replaced by a diaminopropionic acid (Dap) residue that greatly improves the selectivity of the peptide for the voltage-gated potassium channel Kv1.3 (IC50 around 23 pM) against Kv1.1 (1.8 nM), Kv1.4 (37 nM) and Kv1.6 (10 nM) channels. The high selectivity of (Dap22)-Shk is achieved thanks to the strong binding between the Dap and His404 / Asp386 residues of Kv1.3 channel. (Dap22)-ShK inhibits T cell proliferation induced by anti-CD3 at subnanomolar concentrations.
- Molekulargewicht
- 4012.8 kDa
- CAS-Nummer
- 220384-25-8
-
Sie sind hier:
