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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. Zusätzlich bieten wir Ihnen rho Guanine Nucleotide Exchange Factor (GEF) 15 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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pathological elevation of Ephexin5 expression critically drives Abeta (zeige APP Antikörper)-induced memory impairment
upregulation of ARHGEF15 contributes to the development of aggressive PDAC by increasing the growth and motility of the pancreatic cancer cells, thereby worsening the prognosis of these patients.
Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility.
The data of this study support a model in which Ephexin5 serves a dual role in spinogenesis, acting both as a brake on overall spine outgrowth and as a necessary component in the site-specific formation of new spines
Study identified a RhoA (zeige RHOA Antikörper) guanine nucleotide exchange factor (zeige ARHGEF12 Antikörper), Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor triggers Ephexin5 phosphorylation, ubiquitination, and degradation.[Ephexin5]
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene.
, rho guanine nucleotide exchange factor 15
, Rho guanine nucleotide exchange factor (GEF) 15
, Rho guanine exchange factor 15
, rho guanine nucleotide exchange factor 15-like
, Rho GEF 15
, Rho guanine exchange factor (GEF) 15