Zyxin Proteine (ZYX)

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zusätzlich bieten wir Ihnen Zyxin Antikörper (85) und Zyxin Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ZYX 7791 Q15942
Maus ZYX ZYX 22793 Q62523
Ratte ZYX ZYX 114636  
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Showing 6 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
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HOST_Mammalian Cells Human DYKDDDDK-His Tag   20 μg Anmelden zum Anzeigen 6 bis 8 Tage
544,76 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
870,83 €
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ZYX Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,

Weitere Proteine zu Zyxin (ZYX) Interaktionspartnern

Caenorhabditis elegans (C. elegans) Zyxin (ZYX) Interaktionspartner

  1. ZYX-1 is a conserved LIM (zeige PDLIM5 Proteine) domain-containing focal adhesion protein that regulates synapse maintenance in Caenorhabditis elegans

  2. The zyx-1 gene encodes two different isoforms, ZYX-1a and ZYX-1b, which exhibit different roles in dystrophin (zeige DMD Proteine)-dependent muscle degeneration in C. elegans

  3. DYC-1 interacts with ZYX-1, the homologue of the vertebrate focal adhesion LIM domain protein (zeige PDLIM7 Proteine) zyxin.

Fruit Fly (Drosophila melanogaster) Zyxin (ZYX) Interaktionspartner

  1. results show that Zyxin is a functional antagonist of Expanded in growth control

  2. The motor domain of DmMyo20 could specifically bind to actin (zeige ACTB Proteine) filaments in an ATP-independent manner and enhance the interaction between actin (zeige ACTB Proteine) filaments and Zyx102, a downstream component of DmMyo20 in the Fat signaling pathway.

  3. Through epistasis tests, the requirement for Zyx is positioned within the Fat branch of Hippo signaling, downstream of Fat and Dco (zeige CSNK1E Proteine), and upstream of the Yorkie (zeige YAP1 Proteine) kinase Warts.

  4. Reduction of Zyx102 protein levels using RNA-interference results in lethality at the pharate adult stage.

Human Zyxin (ZYX) Interaktionspartner

  1. Increased zyxin expression is associated with asthma.

  2. VASP (zeige VASP Proteine), zyxin and TES (zeige TES Proteine) are tension-dependent members of focal adherens junctions independent of the alpha-catenin (zeige CTNNA1 Proteine)-vinculin (zeige VCL Proteine) module.

  3. Zyxin binding to Ptc2 (zeige PTCH2 Proteine) is due to the interaction of Zyxin 2nd LIM (zeige PDLIM5 Proteine)-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (zeige PTCH2 Proteine) (1159-1412 aa).

  4. ZYX gene may be aging-related gene and involved in Osteoporosis.

  5. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices.

  6. Zyxin, which is thought to be essential for tight cell-to-cell junctions, decreased 1.8-fold in TNF-alpha (zeige TNF Proteine)-treated human brain microvascular endothelial cells.

  7. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.

  8. Zyxin is a novel target for beta-amyloid peptide (zeige APP Proteine) activities in Alzheimer's disease.

  9. Zyxin is suggested to promote growth, migration and invasiveness of fibroblastic type oral squamous cell carcinoma cells by upregulating Rac1 and Cdc42 (zeige CDC42 Proteine).

  10. A stretch-induced signaling pathway in vascular cells leads to the activation of zyxin, a cytoskeletal protein (zeige ACTN1 Proteine) specifically involved in transducing mechanical stimuli.

Mouse (Murine) Zyxin (ZYX) Interaktionspartner

  1. zyxin influences focal adhesion dynamics, that it recruits Tes (zeige TES Proteine) and that this interaction is functional in regulating cell spreading.

  2. Zyxin contributes to the migratory and invasive phenotype evoked by Tead2 (zeige TEAD2 Proteine).

  3. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.

  4. paxillin (zeige PXN Proteine) and zyxin are LIM (zeige PDLIM5 Proteine)-domain adaptor proteins that are recruited to stress fiber strain sites

  5. Zyxin regulates migration of renal epithelial cells through activation of hepatocyte nuclear factor-1beta.

  6. Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 (zeige SMAD3 Proteine) target gene that regulates lung cancer cell motility via integrin alpha5beta1.

  7. a bipartite mechanism for stretch-induced actin remodeling involves mechanosensitive targeting of zyxin to actin stress fibers and localized recruitment of actin regulatory machinery

  8. Mice that lack zyxin function are viable and fertile and display no obvious histological abnormalities in any of the organs examined.Specifically, we evaluated blood platelet function, nervous system development, and skin architecture

  9. LIM-nebulette (zeige NEBL Proteine), Lasp-1 (zeige LASP1 Proteine), and zyxin may play an important role in the organization of focal adhesions

  10. Cooperates with Ena, vasodilator-stimulated phosphoprotein, and caldesmon to influence integrin-dependent cell motility and actin stress fiber remodeling.

Xenopus laevis Zyxin (ZYX) Interaktionspartner

  1. Zyxin binding to Ptc2 (zeige PTCH2 Proteine) is due to the interaction of Zyxin 2nd LIM (zeige PDLIM5 Proteine)-domain (530-590 aa) with the under-membrane region of the cytoplasmic C-terminus of Ptc2 (zeige PTCH2 Proteine) (1159-1412 aa).

  2. Zyxin inhibits Shh (zeige SHH Proteine) signaling during the CNS patterning in Xenopus laevis through interaction with Gli1 (zeige GLI1 Proteine)

  3. These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity.

  4. binding of the LIM2 domain of zyxin with the Engrailed Homology 1 repressor domain of Xanf1 is responsible for the interaction of these proteins.

Zyxin (ZYX) Protein Überblick

Protein Überblick

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Genbezeichner und Symbole assoziert mit Zyxin Proteine (ZYX)

  • ZYXin (zyx-1)
  • Zyxin (Zyx)
  • zyxin (zyx)
  • zyxin (ZYX)
  • Zyxin (zyx)
  • zyxin (EDI_201420)
  • zyxin (LOC100219276)
  • zyxin (Zyx)
  • zyxin (LOC100049724)
  • 9530098H06Rik Protein
  • BcDNA:LD06023 Protein
  • CG32018 Protein
  • DLim-1 Protein
  • Dmel\\CG32018 Protein
  • DmLIM-1 Protein
  • ESP-2 Protein
  • HED-2 Protein
  • lim Protein
  • Lim102EF Protein
  • MGC145270 Protein
  • R75157 Protein
  • zgc:171680 Protein
  • zyx Protein
  • zyx102 Protein
  • Zyx102EF Protein
  • zyxin Protein

Bezeichner auf Proteinebene für Zyxin Proteine (ZYX)

ZYXin family member (zyx-1) , CG32018-PA , CG32018-PB , CG32018-PG , CG32018-PH , Zyx-PA , Zyx-PB , Zyx-PG , Zyx-PH , Zyx102EF , zyxin , hypothetical protein LOC779718 , zyxin-2

GENE ID SPEZIES
174951 Caenorhabditis elegans
317824 Drosophila melanogaster
564246 Danio rerio
706407 Macaca mulatta
779718 Xenopus (Silurana) tropicalis
5914189 Entamoeba dispar SAW760
100011992 Monodelphis domestica
100219276 Taeniopygia guttata
7791 Homo sapiens
768226 Bos taurus
22793 Mus musculus
114636 Rattus norvegicus
482736 Canis lupus familiaris
100524720 Sus scrofa
418300 Gallus gallus
100049724 Xenopus laevis
Ausgewählte Anbieter für Zyxin Proteine (ZYX)
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