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ZIC1 encodes a member of the ZIC family of C2H2-type zinc finger proteins. Zusätzlich bieten wir Ihnen ZIC1 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ZIC1 Primary Antibody für ICC, IHC (fro) - ABIN153383
Lipchina, Elkabetz, Hafner, Sheridan, Mihailovic, Tuschl, Sander, Studer, Betel: Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. in Genes & development 2011
Show all 4 Pubmed References
Human Polyclonal ZIC1 Primary Antibody für ICC, IF - ABIN4366890
Simões-Costa, McKeown, Tan-Cabugao, Sauka-Spengler, Bronner: Dynamic and differential regulation of stem cell factor FoxD3 in the neural crest is Encrypted in the genome. in PLoS genetics 2013
down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor
our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability.
ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)).
ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) and MAPK (zeige MAPK1 Antikörper) signaling pathways and transcription factor FOXO3a (zeige FOXO3 Antikörper).
Loss of ZIC1 expression is associated with malignant pleural mesothelioma.
Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome
Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling
Overexpression of ZIC1 results in inactivation of Shh (zeige SHH Antikörper), PI(3 (zeige PI3 Antikörper))K and MAPK (zeige MAPK1 Antikörper) signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer.
Zic1 (zeige ZIC5 Antikörper), expressed at the anterior neural plate, is necessary and sufficient to promote placode fate.
Pax3 (zeige PAX3 Antikörper) and Zic1 (zeige ZIC5 Antikörper) trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers.
Pax3 (zeige PAX3 Antikörper) and Zic1 (zeige ZIC5 Antikörper) drive induction and differentiation of multipotent, migratory, and functional neural crest in Xenopus embryos.
XMeis3 (zeige MEIS3 Antikörper) protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox (zeige PIPOX Antikörper) or Pax3 (zeige PAX3 Antikörper) genes.
Co-activation of Pax3 (zeige PAX3 Antikörper) and Zic1 (zeige ZIC5 Antikörper), in concert with Wnt (zeige WNT2 Antikörper), plays a decisive role for early neural crest determination in the correct place of the Xenopus ectoderm.
These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 (zeige ZIC5 Antikörper) expression
Zic1 (zeige ZIC5 Antikörper) directly upregulated the Xfeb gene during early neural development.
Zic1 (zeige ZIC5 Antikörper) is an activator of Wnt (zeige WNT2 Antikörper) signaling.
Data show that Pax3 (zeige PAX3 Antikörper) and Zic1 (zeige ZIC5 Antikörper) are necessary and sufficient to promote hatching gland and preplacodal fates, respectively, and that their combined activity is essential to specify the neural crest.
aqp-3b was upregulated by Zic1 (zeige ZIC5 Antikörper)
Brn2 (zeige POU3F2 Antikörper)-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells.
Zic1 and Zic2 (zeige ZIC2 Antikörper) are required for coordinating mature neuronal gene expression patterns.
Association with DNA-bound Pax3 (zeige PAX3 Antikörper) strengthens the ability of both Zic1 and Gli2 (zeige GLI2 Antikörper) to transactivate Myf5 (zeige MYF5 Antikörper) in the epaxial somite.
Zic1 and Zic4 (zeige ZIC4 Antikörper) have both Shh (zeige SHH Antikörper)-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation.
Myf5 (zeige MYF5 Antikörper) activation in newly forming somites is delayed in Zic2 (zeige ZIC2 Antikörper) mutant embryos until the time of Zic1 activation, and both Zic2 (zeige ZIC2 Antikörper) and Myf5 (zeige MYF5 Antikörper) require noggin (zeige NOG Antikörper) for their activation
Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes.
findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation
The functions of Zic1 and Zic3 (zeige ZIC3 Antikörper) may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon.
This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Zic family member 1 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 1
, zinc finger protein 201
, zinc finger protein ZIC 1
, zic protein member 1
, zinc finger protein of the cerebellum 1
, ZIC-related protein 1
, Zic family member 1 (odd-paired homolog)
, odd-paired homolog