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The nuclear localization activity of KRAB domain is a conserved feature of ZNF268.
These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB (zeige NFKB1 Antikörper) signaling.
ZNF268 is a crucial downstream target and effector of GATA-1 (zeige GATA1 Antikörper)
ZNF268 plays a role in early human liver development most likely by functioning through a cytoplasmic mechanism
4 alternative transcripts of ZNF268 were detected in the human blood cells.
ZNF268 gene promoter is atypical and requires an intragenic element located within the first exon that mediates the effect of CREB (zeige CREB1 Antikörper) for its activity
ZNF268 gene may function as a transcriptional activator in the growth and differentiation of cells in development and/or pathogenesis.
HTLV-1 oncoprotein tax (zeige CNTN2 Antikörper) represses ZNF268 expression through the cAMP-responsive element-binding
results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha (zeige TNF Antikörper)-induced NF-kappaB (zeige NFKB1 Antikörper) activation by interacting with the IKK (zeige CHUK Antikörper) complex.
Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 (zeige UPF1 Antikörper) via its promoter.
May be involved in transcriptional regulation.
zinc finger protein 3
, zinc finger protein HZF3