Wolf-Hirschhorn Syndrome Candidate 1 Proteine (WHSC1)

WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Zusätzlich bieten wir Ihnen WHSC1 Antikörper (43) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
WHSC1 7468 O96028
Ratte WHSC1 WHSC1 680537  
WHSC1 107823 Q8BVE8
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top WHSC1 Proteine auf antikoerper-online.de

Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_Escherichia coli (E. coli) Human GST tag MMSET / WHSC1 - SET activity assay using Recombinant Nucleosomes as substrates. Recombinant Nucleosomes were used as substrates in an assay measuring the methyltransferase activity of MMSET / WHSC1 - SET. Activity was detected by fluorography. Recombinant MMSET / WHSC1 - SET protein gel. Recombinant MMSET / WHSC1 - SET run on an SDS-PAGE gel and stained with Coomassie blue. 50 μg Anmelden zum Anzeigen 1 bis 3 Tage
469,44 €
Details
HOST_Baculovirus Human DYKDDDDK Tag MMSET / WHSC1 activity assay. HMT assay measuring the activity of Recombinant MMSET / WHSC1. Activity was detected by fluorography. Recombinant MMSET / WHSC1 protein gel. MMSET / WHSC1 protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 20 μg Anmelden zum Anzeigen 1 bis 3 Tage
469,44 €
Details

WHSC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartnern

Zebrafish Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.

Human Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. In a murine xenograft model using t(4;14)+ KMS11 MM cells harboring an inducible MMSET shRNA, depletion of MMSET enhanced the efficacy of chemotherapy, inhibiting tumor growth and extending survival.

  2. data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer

  3. NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.

  4. Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.

  5. Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.

  6. In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.

  7. results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.

  8. NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation

  9. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (zeige WHSC1L1 Proteine) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  10. It was observed that RE-IIBP induces MEIS1 (zeige MEIS1 Proteine)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20 (zeige RNF20 Proteine).

Mouse (Murine) Wolf-Hirschhorn Syndrome Candidate 1 (WHSC1) Interaktionspartner

  1. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  2. WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies

  3. Histone H3 (zeige HIST3H3 Proteine) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (zeige RUNX2 Proteine) and p300 (zeige NOTCH1 Proteine) in the activation of bone-related genes

  4. all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Proteine), HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Proteine), and Pr-Set7 (zeige SETD8 Proteine) were not affected by ubH2A.

  5. WHSC1 links transcription elongation to HIRA (zeige HIRA Proteine)-mediated histone H3.3 (zeige H3F3A Proteine) deposition.

  6. H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome

WHSC1 Protein Überblick

Protein Überblick

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

Genbezeichner und Symbole assoziert mit WHSC1

  • Wolf-Hirschhorn syndrome candidate 1 (WHSC1)
  • Wolf-Hirschhorn syndrome candidate 1 (whsc1)
  • Wolf-Hirschhorn syndrome candidate 1 (Whsc1)
  • Wolf-Hirschhorn syndrome candidate 1 (human) (Whsc1)
  • 5830445G22Rik Protein
  • 9430010A17Rik Protein
  • AW555663 Protein
  • C130020C13Rik Protein
  • D030027O06Rik Protein
  • D930023B08Rik Protein
  • fc12c04 Protein
  • mKIAA1090 Protein
  • MMSET Protein
  • NSD2 Protein
  • REIIBP Protein
  • RGD1565590 Protein
  • si:rp71-77d7.2 Protein
  • TRX5 Protein
  • WHS Protein
  • WHSC1 Protein
  • Whsc1l Protein
  • wu:fc12c04 Protein
  • wu:fi20c01 Protein

Bezeichner auf Proteinebene für WHSC1

Wolf-Hirschhorn syndrome candidate 1 protein , Wolf-Hirschhorn syndrome candidate 1 , probable histone-lysine N-methyltransferase NSD2 , IL5 promoter REII region-binding protein , histone-lysine N-methyltransferase NSD2 , multiple myeloma SET domain containing protein type III , nuclear SET domain-containing protein 2 , trithorax/ash1-related protein 5 , multiple myeloma SET domain-containing protein , wolf-Hirschhorn syndrome candidate 1 protein homolog

GENE ID SPEZIES
461070 Pan troglodytes
540769 Bos taurus
100000709 Danio rerio
100051090 Equus caballus
100125213 Xenopus (Silurana) tropicalis
479077 Canis lupus familiaris
7468 Homo sapiens
422897 Gallus gallus
680537 Rattus norvegicus
107823 Mus musculus
Ausgewählte Anbieter für WHSC1 Proteine (WHSC1)
Haben Sie etwas anderes gesucht?