Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
WHSC1 encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. Zusätzlich bieten wir Ihnen WHSC1 Antikörper (41) und viele weitere Produktgruppen zu diesem Protein an.
Showing 5 out of 5 products:
These results indicate that DrWhsc1 is a functional homolog of WHSC1 and that the SET domain of DrWhsc1 is essential for di-methylation of histone H3K36 in zebrafish.
data suggest multiple myeloma SET domain containing protein(MMSET) may play a role in the inhibitory effect of metformin on prostate cancer and could serve as a potential novel therapeutic target for prostate cancer
NSD2 overexpression is significantly associated with high risk of relapse and poor survival in tamoxifen-treated ER-positive breast cancer patients via coordinated activation of pentose phosphate pathway enzymes.
Results show that WHSC1 is hypomethylated in cervical cancer cells and tissues. Both methylation and mRNA expression of WHSC1 were significantly correlated with lymph node metastasis and the overall survival of patients.
Results showed that high levels of MMSET in the myeloma-like cells drove the formation of hypermethyled proteoforms containing H3K36me2 co-existent with the repressive marks H3K9me2/3 and H3K27me2/3.
In MMSET-depleted cells there are defects in DNA replication and a decreased association with chromatin.
results identify a pivotal role for NSD2 binding to its catalytic product in regulating its cellular functions, and suggest a model for how this interaction may facilitate epigenetic spreading and propagation of H3K36me2.
NSD2 preferentially catalyzes the dimethylation of H3K36 along with a reduced preference for H3K36 monomethylation
Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 (zeige WHSC1L1 Proteine) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.
It was observed that RE-IIBP induces MEIS1 (zeige MEIS1 Proteine)-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20 (zeige RNF20 Proteine).
Results show that WHSC1 is overexpressed in Squamous cell carcinoma of the head and neck (SCCHN) and that it promotes cell-cycle progression through activation of NEK7 (zeige NEK7 Proteine), indicating its potential role as an oncogenic force in SCCHN.
WHSC1-deficient mice display craniofacial defects that overlap with Wolf-Hirschhorn syndrome, including cochlea anomalies
Histone H3 (zeige HIST3H3 Proteine) lysine 36 methyltransferase Whsc1 promotes the association of Runx2 (zeige RUNX2 Proteine) and p300 (zeige NOTCH1 Proteine) in the activation of bone-related genes
all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Proteine), HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Proteine), and Pr-Set7 (zeige SETD8 Proteine) were not affected by ubH2A.
WHSC1 links transcription elongation to HIRA (zeige HIRA Proteine)-mediated histone H3.3 (zeige H3F3A Proteine) deposition.
H3K36me3-specific histone methyltransferase WHSC1 (also NSD2 or MMSET) functions in transcriptional regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschhorn syndrome
This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4\;14)(p16.3\;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.
Wolf-Hirschhorn syndrome candidate 1 protein
, Wolf-Hirschhorn syndrome candidate 1
, probable histone-lysine N-methyltransferase NSD2
, IL5 promoter REII region-binding protein
, histone-lysine N-methyltransferase NSD2
, multiple myeloma SET domain containing protein type III
, nuclear SET domain-containing protein 2
, trithorax/ash1-related protein 5
, multiple myeloma SET domain-containing protein
, wolf-Hirschhorn syndrome candidate 1 protein homolog