Vaccinia Related Kinase 1 (VRK1) ELISA Kits

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. Zusätzlich bieten wir Ihnen Vaccinia Related Kinase 1 Antikörper (73) und Vaccinia Related Kinase 1 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
VRK1 7443 Q99986
VRK1 22367 Q80X41
Anti-Ratte VRK1 VRK1 362779  
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Top Vaccinia Related Kinase 1 ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.062 ng/mL 0.156-10 ng/mL 96 Tests Anmelden zum Anzeigen 15 bis 17 Tage
$908.41
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Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Weitere ELISA Kits für Vaccinia Related Kinase 1 Interaktionspartner

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (zeige TP53 ELISA Kits).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. VRK1 AND VRK2 (zeige VRK2 ELISA Kits) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  2. VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (zeige CDK2 ELISA Kits) and p27(kip1 (zeige CDKN1B ELISA Kits)).

  3. we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma

  4. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (zeige FAM126A ELISA Kits).

  5. VRK1 is a novel regulator of CBs (zeige CBS ELISA Kits) dynamics and stability in cell cycle by protecting coilin (zeige COIL ELISA Kits) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  6. VRK1 regulation of NBS1 (zeige NBN ELISA Kits) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  7. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (zeige ATM ELISA Kits) Proteins.

  8. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (zeige APP ELISA Kits)). APP (zeige APP ELISA Kits) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (zeige APP ELISA Kits)-dependent mechanism.

  9. VRK1 can contribute to make these tumors more resistant to DNA damage-based therapies, such as ionizing radiation or doxorubicin, which is consistent with its association to a poor prognosis in ER positive breast cancer.

  10. VRK1 deficiency disrupts nuclear envelope morphology and leads to BAF (zeige BANF1 ELISA Kits) retention on mitotic chromosomes.

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (zeige APP ELISA Kits)). APP (zeige APP ELISA Kits) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (zeige APP ELISA Kits)-dependent mechanism.

  2. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  3. Protein kinase (zeige CDK7 ELISA Kits) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (zeige TP53 ELISA Kits)-dependent manner.

  4. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  5. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  6. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  7. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (zeige HIST3H3 ELISA Kits) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Genbezeichner und Symbole assoziert mit VRK1

  • vaccinia related kinase 1 (vrk1) Antikörper
  • vaccinia related kinase 1 (VRK1) Antikörper
  • vaccinia related kinase 1 (LOC100340357) Antikörper
  • Protein VRK-1 (vrk-1) Antikörper
  • vaccinia related kinase 1 (Vrk1) Antikörper
  • 51PK Antikörper
  • MGC64390 Antikörper
  • MGC75762 Antikörper
  • PCH1 Antikörper
  • PCH1A Antikörper
  • VRK1 Antikörper
  • wu:fe16f06 Antikörper
  • zgc:56266 Antikörper

Bezeichner auf Proteinebene für VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

GENE ID SPEZIES
380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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