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UNC5B encodes a member of the netrin family of receptors. Zusätzlich bieten wir Ihnen Unc-5 Homolog B (C. Elegans) Antikörper (45) und Unc-5 Homolog B (C. Elegans) Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation
UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis.
fibronectin leucine-rich transmembrane protein 2 (FLRT2 (zeige FLRT2 Proteine)), a repulsive ligand of the UNC5 receptor family for neurons, is unexpectedly expressed in endothelial cells specifically in the placental labyrinth.
Blockade of Netrin-1 (zeige NTN1 Proteine)/Unc5b by monoclonal antibodies prevents bone destruction and reduces the severity of K/BxN serum transfer-induced arthritis
Data showed that albuminuria was significantly more pronounced in mice with proximal tubule specific deletion of UNC5B.
UNC5B receptor deletion exacerbates DSS (zeige PMP22 Proteine)-induced colitis in mice by increasing epithelial cell apoptosis.
unc5b expression is greater in adipose tissue of obese versus lean mice.
UNC5B plays a critical role in cell survival and kidney injury through Akt (zeige AKT1 Proteine)-mediated inactivation of p53 (zeige TP53 Proteine) in response to stress.
These studies demonstrate an important role for UNC5B during myocardial ischemia-reperfusion injury.
a significant role for UNC5B in the development of hepatic IRI and identified UNC5B as a potential drug target to prevent liver dysfunction in the future.
Robo4 (zeige ROBO4 Proteine) specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
Netrin-1 (zeige NTN1 Proteine) acting through the UNC5B receptor reduces renal ischemia-reperfusion injury and its associated renal inflammation.
These findings point to a new important function of UNC5B and provide a potential basis for hASCs-mediated bone regeneration.
Our results suggest that UNC5B overexpression inhibits the proliferation and migration of bladder cancer cells by inducing cell cycle arrest at G2/M phase.
UNC5B expression is decreased in bladder cancer cells compared to normal bladder cell lines.
Data indicate that dysregulation of expression of netrin-1 NTN1 (zeige NTN1 Proteine) in smooth muscle cell (SMC (zeige DYM Proteine)) and its chemorepulsive receptor UNC5B in macrophages are involved in the development of atherosclerosis and unstable plaques.
unc5b expression is greater in adipose tissue of obese versus lean subjects.
Higher netrin-1 (zeige NTN1 Proteine) and lower UNC5B expression in all prostate carcinoma cell lines indicated that netrin-1 (zeige NTN1 Proteine) and UNC5B could be used to predict metastasis.
Low UNC5B expression was an independent risk factor for postoperative recurrence in patients with different stages and grades bladder cancer.
UNC5B protein expressed in macrophages in hypoxic regions of atherosclerotic regions in human.
UNC5B was downregulated in kidney carcinoma.
Reducing Unc5b levels in Sip1 knockout slices and brains rescues cell migration in cortical interneurons.
findings show that the netrin-1 (zeige NTN1 Proteine) and p53RDL1 system may regulate the induction of apoptosis in porcine granulosa cells
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene.
netrin receptor UNC5B
, protein unc-5 homolog 2
, protein unc-5 homolog B
, unc-5 homolog 2
, unc5 homolog 2
, transmembrane receptor Unc5H2
, p53-regulated receptor for death and life protein 1
, unc-5 homolog C
, p53-regulated receptor for death and life
, unc-5 homolog B (C. elegans)
, UNC-5 receptor
, protein Xunc-5
, protein unc-5 homolog