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The protein encoded by UBE2K belongs to the ubiquitin-conjugating enzyme family. Zusätzlich bieten wir Ihnen Ubiquitin-Conjugating Enzyme E2K Proteine (17) und Ubiquitin-Conjugating Enzyme E2K Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 113 products:
Human Polyclonal UBE2K Primary Antibody für WB - ABIN1881965
Bae, Kho, Lee, Rhim, Kang: Hip2 interacts with and destabilizes Smac/DIABLO. in Biochemical and biophysical research communications 2010
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Human Polyclonal UBE2K Primary Antibody für IF, WB - ABIN1882088
Furukawa, Kubo, Kikuchi, Tokura, Fujita, Sakurabayashi: Regulation of macrophage-specific gene expression by degenerated lipoproteins. in Electrophoresis 2000
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Human Polyclonal UBE2K Primary Antibody für IHC (p), IHC - ABIN268582
Kalchman, Graham, Xia, Koide, Hodgson, Graham, Goldberg, Gietz, Pickart, Hayden: Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. in The Journal of biological chemistry 1996
Cow (Bovine) Polyclonal UBE2K Primary Antibody für WB - ABIN2787510
Christensen, Brzovic, Klevit: E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. in Nature structural & molecular biology 2007
Show all 2 Pubmed References
The crystal structure of a Ube2K~ubiquitin conjugate has been described, and it was shown that even though it is monomeric, Ube2K can synthesize Lys48-linked ubiquitin chains.
Hip2, a ubiquitin-conjugating enzyme (zeige Ube2t Antikörper), can overcome radiation-induced G2/M cell cycle arrest and trigger the entry into mitosis.
An extract of bark from the tropical rainforest plant Byrsonima crassifolia was screened for inhibition of diubiquitin (zeige UBD Antikörper) formation by the human ubiquitin-conjugating enzyme E2-25K.
one of the roles of the C-terminal UBA domain, in the context of E2-25K, is to increase processivity in Lys48-linked polyubiquitin (zeige UBB Antikörper) chain synthesis, possibly through increased binding to the ubiquitinated substrate.
Results suggest that the interaction between E2-25K and UBB (zeige UBB Antikörper)(+1) is critical for the synthesis and accumulation of UBB (zeige UBB Antikörper)(+1)-anchored polyubiquitin (zeige UBB Antikörper), which results in proteasomal inhibition and neuronal cell death.
This study suggests that Hip2 might be involved in the regulation of Smac (zeige DIABLO Antikörper)-mediated apoptosis.
Results suggest that in permeabilized, US11-expressing cells polyubiquitination of the MHC class I heavy chain substrate can be catalyzed by E2-25K.
E2-25K is involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death.
E2-25K has a crucial role in oxidative stress and cerebral Ischemia/Reperfusion-induced damage through inhibiting proteasome via its SUMOylation.
E2-25K/Hip-2 is thus an essential upstream regulator of the expression and activation of caspase-12 (zeige CASP12 Antikörper) in endoplasmic reticulum stress-mediated Abeta (zeige APP Antikörper) neurotoxicity.
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene.
ubiquitin-conjugating enzyme E2K (UBC1 homolog)
, huntingtin interacting protein 2
, ubiquitin-conjugating enzyme E2-25K
, ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
, ubiquitin-conjugating enzyme E2 K
, ubiquitin-conjugating enzyme E2-25 kDa
, huntingtin-interacting protein 2
, ubiquitin carrier protein
, ubiquitin-conjugating enzyme E2(25K)
, ubiquitin-conjugating enzyme E2-25 KDA
, ubiquitin-protein ligase