Ubiquitin Specific Peptidase 37 Proteine (USP37)

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Zusätzlich bieten wir Ihnen USP37 Antikörper (35) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP37 57695 Q86T82
Maus USP37 USP37 319651 Q8C0R0
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Top USP37 Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 20 Days
$785.40
Details

USP37 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,

Weitere Proteine zu Ubiquitin Specific Peptidase 37 (USP37) Interaktionspartnern

Human Ubiquitin Specific Peptidase 37 (USP37) Interaktionspartner

  1. USP37 interacts with Cdt1 (zeige CDT1 Proteine) and is able to de-ubiquitinate Cdt1 (zeige CDT1 Proteine) in vivo and, USP37 is able to regulate the loading of MCM complexes onto the chromatin.

  2. USP37 associates with cohesin and contributes to sister chromatid resolution. Cohesion defects are rescued by expression of an RNAi-resistant USP37, but not the catalytically impaired USP37(C350A) mutant.

  3. USP37 is significantly upregulated in human lung cancer tissues, where its expression is positively correlated with c-Myc (zeige MYC Proteine) protein expression.

  4. These results suggested that the UIMs in USP37 contribute to the full enzymatic activity, but not ubiquitin chain substrate specificity, of USP37 possibly by holding the ubiquitin chain substrate in the proximity of the catalytic core.

  5. our findings of USP37-modulating PLZF (zeige ZBTB16 Proteine)/RARA (zeige RARA Proteine) stability and cell transformation suggest that USP37 is a potential therapeutic target for PLZF (zeige ZBTB16 Proteine)/RARA (zeige RARA Proteine)-associated APL (zeige FASL Proteine)

  6. USP37 links REST to the control of p27 (zeige PAK2 Proteine) stability and cell proliferation.

  7. Skp1 (zeige SKP1 Proteine)-Cul1 (zeige CUL1 Proteine)-F-box ubiquitin ligase (SCF (zeige KITLG Proteine)(betaTrCP (zeige BTRC Proteine)))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry

  8. The deubiquitinase USP37 binds CDH1 (zeige CDH1 Proteine) and removes degradative polyubiquitin (zeige UBB Proteine) from cyclin A (zeige CCNA2 Proteine). USP37 was induced by E2F (zeige E2F1 Proteine) factors in G1, peaked at G1/S, and was degraded in late mitosis. Phosphorylation of USP37 by CDK2 (zeige CDK2 Proteine) stimulated its full activity.

USP37 Protein Überblick

Protein Überblick

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-630 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (By similarity).

Genbezeichner und Symbole assoziert mit USP37

  • ubiquitin specific peptidase 37 (USP37)
  • ubiquitin specific peptidase 37 (usp37)
  • ubiquitin specific peptidase 37 (Usp37)
  • 4932415L06Rik Protein
  • C330008N13Rik Protein
  • wu:fi15b04 Protein
  • wu:fi38d03 Protein
  • zgc:152882 Protein
  • zgc:153999 Protein

Bezeichner auf Proteinebene für USP37

ubiquitin specific peptidase 37 , ubiquitin specific protease 37 , ubiquitin carboxyl-terminal hydrolase 37-like , deubiquitinating enzyme 37 , tmp_locus_50 , ubiquitin carboxyl-terminal hydrolase 37 , ubiquitin thioesterase 37 , ubiquitin thiolesterase 37 , ubiquitin-specific-processing protease 37 , Deubiquitinating enzyme 37 , Ubiquitin carboxyl-terminal hydrolase 37 , Ubiquitin thiolesterase 37 , Ubiquitin-specific-processing protease 37 , fi15b04 , usp39

GENE ID SPEZIES
459944 Pan troglodytes
701732 Macaca mulatta
100124313 Xenopus (Silurana) tropicalis
100155158 Sus scrofa
100347231 Oryctolagus cuniculus
100389662 Callithrix jacchus
100481404 Ailuropoda melanoleuca
100541053 Meleagris gallopavo
100602108 Nomascus leucogenys
57695 Homo sapiens
319651 Mus musculus
407168 Bos taurus
488523 Canis lupus familiaris
424216 Gallus gallus
768201 Danio rerio
Ausgewählte Anbieter für USP37 Proteine (USP37)
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