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Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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A novel USP26 variant p.R344W is associated with nonobstructive azoospermia probably through affecting androgen receptor (zeige AR Antikörper) function.
The interaction between USP26 and Mdm2 (zeige MDM2 Antikörper), and the subsequent deubiquitination of Mdm2 (zeige MDM2 Antikörper), serves, most probably to regulate Mdm2 (zeige MDM2 Antikörper). Future therapeutic modalities that interfere with the association between USP26 and Mdm2 (zeige MDM2 Antikörper) will be used to destabilize the ligase in malignancies where it is upregulated.
identification in a normozoospermic man of a nonsense mutation (c.882C>A) which causes the production of a truncated protein, suggests a marginal role of USP26 in male spermatogenesis
Evidence from both enzymatic and meta-analyses does not support a direct association between USP26 variants and male infertility
There is an association of alteration in USP26 with male infertility, especially in azoospermia and in the Asian population. [Meta-Analysis]
there is a significant difference in USP26 gene expression between the obstructive azoospermia, complete maturation arrest samples and Sertoli Cell-Only Syndrome samples
results indicated the variation of USP26 was not directly associated with human sperm count but suggested it might be a potential role in sperm motility
The nucleotide polymorphisms of the Usp26 gene might be closely related with idiopathic male infertility, and exert a negative effect on the testis function.
USP26 assembles with androgen receptors (AR)and other cofactors in subnuclear foci and serves to counteract hormone-induced AR ubiquitination, thereby contributing to the regulation of AR transcriptional activity.
Alterations in the USP26 gene may be involved in male infertility or might increase the risk of male infertility. These patients showed 370-371insACA, 494T>C and 1423C>T causing T123-124ins, L165S and H475Y, respectively
RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines
Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
universal stress protein
, ubiquitin carboxyl-terminal hydrolase 26
, ubiquitin specific peptidase 26
, ubiquitin-specific protease 26
, ubiquitin carboxyl-terminal hydrolase 26-like
, deubiquitinating enzyme 26
, ubiquitin specific protease 26
, ubiquitin thioesterase 26
, ubiquitin thiolesterase 26
, ubiquitin-specific processing protease 26
, ubiquitin-specific-processing protease 26