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E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Zusätzlich bieten wir Ihnen UBE3C Antikörper (22) und viele weitere Produktgruppen zu diesem Protein an.
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data reveal that high UBE3C expression contributes to glioma progression by ubiquitination and degradation of ANXA7 (zeige ANXA7 Proteine), and thus presents a novel and promising target for glioma therapy.
these observations suggest that UBE3C plays an important role in RCC (zeige XRCC1 Proteine) development and progression, and UBE3C may be a novel target for prevention and treatment of ccRCC.
UBE3C is a mutant candidate oncogene (zeige RAB1A Proteine) involved in tumor development and progression of hepatocellular carcinoma.
knockdown renders cells more susceptible to the Hsp90 (zeige HSP90 Proteine) inhibitor 17-AAG (zeige MPG Proteine), suggesting that UBE3C protects against the harmful accumulation of protein fragments arising from incompletely degraded proteasome substrates.
Our findings provide evidence that variations in UBE3C are potent genetic markers of nasal polyps development in Korean asthmatics.
negatively regulates type I interferon (zeige IFNA Proteine) through ubiquitination of the transcription factors
TIP120B (zeige CAND2 Proteine) is a specific substrate of KIAA10; both are highly expressed in human skeletal muscle, suggesting that KIAA10 may regulate TIP120B (zeige CAND2 Proteine) homeostasis specifically in this tissue.
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
ubiquitin-protein ligase E3C
, ubiquitin protein ligase E3C
, ubiquitin-protein isopeptide ligase (E3)
, ubiquitin-protein ligase E3C-like