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UPF1 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Zusätzlich bieten wir Ihnen UPF1 Regulator of Nonsense Transcripts Homolog (Yeast) Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 65 products:
Human Polyclonal UPF1 Primary Antibody für WB - ABIN151832
Silva, Pereira, Morgado, Kong, Martins, Faustino, Liebhaber, Romão: The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context. in RNA (New York, N.Y.) 2006
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Human Polyclonal UPF1 Primary Antibody für WB - ABIN1882125
Mendell, ap Rhys, Dietz: Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. in Science (New York, N.Y.) 2002
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Human Polyclonal UPF1 Primary Antibody für IP, PLA - ABIN438392
Martins, Proença, Silva, Barbosa, Silva, Faustino, Romão: Alternative polyadenylation and nonsense-mediated decay coordinately regulate the human HFE mRNA levels. in PLoS ONE 2012
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Human Polyclonal UPF1 Primary Antibody für WB - ABIN151833
Silva, Ribeiro, Inácio, Liebhaber, Romão: Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay. in RNA (New York, N.Y.) 2008
Human Polyclonal UPF1 Primary Antibody für PLA, WB - ABIN151834
Luke, Azzalin, Hug, Deplazes, Peter, Lingner: Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay. in Nucleic acids research 2008
Human Polyclonal UPF1 Primary Antibody für WB - ABIN388607
Ohnishi, Yamashita, Kashima, Schell, Anders, Grimson, Hachiya, Hentze, Anderson, Ohno: Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. in Molecular cell 2003
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results indicate that UPF1 can dissociate miRNAs from their mRNA targets, making the miRNAs susceptible to Tudor-staphylococcal/micrococcal-like nuclease (zeige DCLRE1C Antikörper) (TSN (zeige TSN Antikörper))-mediated miRNA decay.
Overexpression of UPF1 inhibited cell proliferation, cell cycle progression, cell migration and invasion, and promoted cell apoptosis in gastric cancer cells. Moreover, the UPF1-mediated inhibition of gastric cancer progression was reversed by overexpression of MALAT1.
The nucleic acids processing activities of UPF1 are consistent with its function in mRNA regulation and suggest that roles in DNA replication could also be influenced by base sequence.
MARVELD1 (zeige MARVELD1 Antikörper) substantially inhibits nonsense-mediated RNA decay by decreasing the pioneer round of translation but not steady-state translation, and is an important component of the molecular machinery containing UPF1 and Y14 (zeige RBM8A Antikörper). MARVELD1 (zeige MARVELD1 Antikörper) promotes the dissociation of SMG1 (zeige SMG1 Antikörper) from UPF1, resulting in the repression of serine phosphorylation of UPF1, and subsequently blocks the recruitment of SMG5 (zeige SMG5 Antikörper).
UPF1 acts as an E3 ligase via its RING domain to promote MYOD protein ubiquitination and degradation and repress myogenesis.
Upregulation of SNHG6 regulates ZEB1 (zeige ZEB1 Antikörper) expression by competitively binding miR (zeige MLXIP Antikörper)-101-3p and interacting with UPF1 in hepatocellular carcinoma, promoting tumor growth and metastasis.
Study showed that UPF1 was down-regulated due to promoter hypermethylation in hepatocellular carcinoma tissues which correlated with decreased survival.
CARM1 (zeige CARM1 Antikörper) associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy.
Upf1 is a RNA helicase (zeige DDX46 Antikörper) essential for nonsense-mediated mRNA decay. Once recruited onto NMD mRNA targets, Upf1 can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.
Results present evidence for a critical role for Upf1 ATPase (zeige DNAH8 Antikörper) activity in nonsense-mediated decay target discrimination, with preferential ATPase (zeige DNAH8 Antikörper)-dependent release of Upf1 from non-target mRNAs as part of the underlying mechanism.
Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .
results identify novel nonsense-mediated mRNA decay (NMD) determinants and targets and provide context for understanding the impact of UPF1 and NMD on the murine embryonic stem cell transcriptome
results suggest that the role of SMG-5 (zeige ZCCHC11 Antikörper) is to direct protein phosphatase 2A to its SMG-2 substrate
SMG-2 interacts with SMG-3 (zeige UPF2 Antikörper), SMG-3 (zeige UPF2 Antikörper) interacts with SMG-4, and SMG-2 interacts indirectly with SMG-4 via shared interactions with SMG-3 (zeige UPF2 Antikörper). SMG-2 preferentially associates with PTC (zeige PTCH1 Antikörper)-containing mRNAs.
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.
ATP-dependent helicase RENT1
, UP Frameshift 1
, delta helicase
, nonsense mRNA reducing factor 1
, regulator of nonsense transcripts 1
, smg-2 homolog, nonsense mediated mRNA decay factor
, up-frameshift mutation 1 homolog
, up-frameshift suppressor 1 homolog
, yeast Upf1p homolog
, Regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)
, LOW QUALITY PROTEIN: regulator of nonsense transcripts 1
, UPF1 regulator of nonsense transcripts homolog S homeolog