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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. Zusätzlich bieten wir Ihnen UGCG Antikörper (38) und UGCG Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Results suggest that the changes of DNA methylation (zeige HELLS ELISA Kits) status of the glucosylceramide synthase (GCS) promoter correlates with multidrug resistance in breast cancer.
Glucosylceramide synthase upregulation is associated with sorafenib resistance in hepatocellular carcinoma.
GCS (zeige GCLC ELISA Kits) was upregulated in colorectal carcinoma tissues compared to control tissues.
We found upregulation of specific sphingolipid enzymes, namely sphingomyelin synthase 1 (SMS1 (zeige SGMS1 ELISA Kits)), sphingomyelinase 3 (SMPD3), and glucosylceramide synthase (GCS) in the endometrium of endometriotic women.
Our data demonstrates a correlation between the expression of the GCS (zeige GCLC ELISA Kits) protein and ER-positive/HER-2 (zeige ERBB2 ELISA Kits) negative breast cancer
our work indicates that some UGCG polymorphisms are modifying factors in the severity of GD.
GCS (zeige GCLC ELISA Kits) was upregulated in PTCs and might be an independent factor affecting prognosis.
Glucosylceramide synthase mRNA were reduced by 62%.
The results thus show that ARF6 (zeige ARF6 ELISA Kits) regulates neuronal differentiation through an effect on glucosylceramide synthase and glucosylceramide levels.
DOX could modulate the expression of GCS (zeige GCLC ELISA Kits) through the Sp1 (zeige PSG1 ELISA Kits) site of GCS (zeige GCLC ELISA Kits) promoter in ERalpha (zeige ESR1 ELISA Kits)-positive breast cancer cells
we report the development of a novel, orally available glucosylceramide synthase inhibitor (Genz-682452) with pharmacological and safety profiles that have potential for treating Fabry disease.
These results suggest that neuronal glucosylceramide synthase expression modulates mediobasal hypothalamus insulin (zeige INS ELISA Kits) signaling and white adipose tissue function in fasted mice.
we measured the expression and activities of Pgp and GCS, UDP-glucose levels, cellular uptake of C12-NBD-ceramide (a fluorescent analogue of ceramide) and ceramide-induced cell death in S and R cells.
Data indicate that verexpression of glucosylceramide synthase in myotubes induces glucosylceramide but enhances insulin (zeige INS ELISA Kits) signaling.
Data indicate that mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosylceramide synthase and lactosylceramide synthase showed marked reduction in tumor volume.
The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase).
Data indicate that mice with cerebroside sulfotransferases (Cst (zeige CORT ELISA Kits)) and UDP-glucose:ceramide glucosyltransferase (Ugcg)/Cst (zeige CORT ELISA Kits) deficiency had lower ammonium excretion.
glycosphingolipids in hepatocytes are not essential for sterol, glucose, or lipoprotein metabolism. Ugcg inhibitors exert their effect on hepatocytes either independently of GSL (zeige CTSA ELISA Kits) or mediated by other (liver) cell types.
Ugcg and Ugt8a (zeige UGT8 ELISA Kits) deficient oligodendroglial did not exhibit any phenotypic or myelin structural abnormalities; abundant and structurally intact myelin can form in their absence
Shortly after birth UgcG deficient mice showed dysfunction of cerebellum and peripheral nerves, associated with structural defects
Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.
, UDP-glucose ceramide glucosyltransferase b
, ceramide glucosyltransferase b
, ceramide glucosyltransferase-B
, UDP-glucose:N-acylsphingosine D-glucosyltransferase
, glucosylceramide synthase
, ectoplacental cone, invasive trophoblast giant cells, extraembryonic ectoderm and chorion sequence 21
, UDP-glucose:ceramide glycosyltransferase