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The enzyme encoded by TYR catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. Zusätzlich bieten wir Ihnen Tyrosinase Antikörper (209) und Tyrosinase Kits (56) und viele weitere Produktgruppen zu diesem Protein an.
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Retinal pigment epithelium (which normally expresses tyrosinase) secretes a modulatory factor, possibly L-DOPA, which regulates light adaptation in the retinal circuitry.
Transcription of the tyrosinase gene family in an Atlantic salmon leukocyte cell line (SHK (zeige SHPK Proteine)-1) is influenced by temperature, but not by virus infection or bacterin stimulation.
Mutations in tyrosinase gene is associated with Oculocutaneous albinism type 1.
tyrosinase as a potential GPR143 (zeige GPR143 Proteine) binding protein opens new avenues for investigating the mechanisms that regulate pigmentation and neurogenesis.
Aberrant tyrosinase expression in an atypical fibroxanthoma
Findings suggested that miR (zeige MLXIP Proteine)-330-5p represents a potential tumor-suppressive miRNA and plays an important role in cutaneous malignant melanoma progression by suppressing TYR and PDIA3 (zeige PDIA3 Proteine) expression.
Four missense substitutions (p.Arg239Trp, p.Ser192Tyr, p.Ser44Arg and p.Arg77Gln) were identified in tyrosinase in the families with oculocutaneous albinism linkage, and another missense substitution (p.Gln272Lys) was identified in the family with OCA4 linkage
LEF-1 (zeige LEF1 Proteine) and MITF (zeige MITF Proteine) regulate tyrosinase gene transcription in vitro via binding to its promoter.
Data show that mutant microphthalmia-associated transcription factor (MITF (zeige MITF Proteine)) with loss of localization signals (NLS (zeige ALDH1A2 Proteine)) has failed to transactivate the transcriptional activities of target gene tyrosinase (TYR), which can cause Waardenburg syndrome.
The tyrosinase gene was examined in 23 unrelated patients with autosomal recessive ocular albinism or nonsyndromic oculocutaneous albinism. TYR gene mutations were identi fi ed in 14 (app (zeige APP Proteine). 60%) albinism patients.
The two mutations (c.1114delG in the TYR gene and c.1426A>G in the OCA2 gene) may be responsible for partial clinical manifestations of Oculocutaneous albinism.
Molecular analysis identified two compound heterozygous TYR mutations known to cause OCAIA and cosegregate with oculocutaneous albinism. In addition, we identified a novel heterozygous PAX6 (zeige PAX6 Proteine) mutation confirming the atypical aniridia phenotype.
This study demonstrates the utility of CRISPR-Cas9 system in generating domain-specific in-frame deletions and helps gain further insights into structure-function of Tyr gene.
These results suggest that the tyrosinase-induced metabolism of rhodendrol causes melanocyte toxicity.
Data indicate that both ephedrannins A and B were competitive inhibitors of mushroom tyrosinase.
STAP-2 (zeige STAP2 Proteine) colocalized with tyrosinase in lysosomes and protected tyrosinase from protein degradation in B16F10 melanoma cells.
Docosahexaenoic acid inhibits melanogenesis in B16F10 cells in vitro through increased tyrosinase degradation.
Studied upregulation by Kaliziri extract of tyrosinase, TRP-1 (zeige TRPC1 Proteine), TRP-2 (zeige DCT Proteine) and MITF (zeige MITF Proteine) expression in murine B16 melanoma cells.
The albino mutation of tyrosinase alters ocular angiogenic responsiveness.
Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.
activated by ascorbic acid in B16 melanoma via p38 MAPK (zeige MAPK14 Proteine) signaling and upregulation of melanogenic regulatory factors
Effect of zibuganshenfang on the expression and activity of tyrosinase on B16 cells
we identified some genes that are related to fur formation, including Tyrosinase-related protein 1 (TYRP1 (zeige TYRP1 Proteine)) and Tyrosinase (TYR), as well as genes with unknown functions.
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
, hypothetical protein
, tyrosinase (oculocutaneous albinism IA)
, monophenol monooxygenase
, oculocutaneous albinism IA
, tumor rejection antigen AB
, albino locus protein