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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Zusätzlich bieten wir Ihnen Tumor Necrosis Factor Receptor Superfamily, Member 11b Kits (88) und Tumor Necrosis Factor Receptor Superfamily, Member 11b Proteine (36) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal TNFRSF11B Primary Antibody für CyTOF, FACS - ABIN252469
Kobayashi, Hashimoto, Miyamoto, Kanaoka, Miyazaki-Kawashita, Nakashima, Shibata, Kobayashi, Kato, Sakai: Force-induced osteoclast apoptosis in vivo is accompanied by elevation in transforming growth factor beta and osteoprotegerin expression. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2001
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Cow (Bovine) Polyclonal TNFRSF11B Primary Antibody für IHC, ELISA - ABIN1582232
Fradet, Sorel, Bouazza, Goehrig, Dépalle, Bellahcène, Castronovo, Follet, Descotes, Aubin, Clézardin, Bonnelye: Dual function of ERR? in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin. in Cancer research 2011
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Human Monoclonal TNFRSF11B Primary Antibody für IHC, ELISA - ABIN969440
Golledge, Biros, Clancy, Cooper, Palmer, Norman: A single-nucleotide polymorphism in the gene encoding osteoprotegerin is associated with diastolic blood pressure in older men. in American journal of hypertension 2009
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Human Monoclonal TNFRSF11B Primary Antibody für ICC, FACS - ABIN969439
Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ... in American journal of human genetics 2009
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Human Monoclonal TNFRSF11B Primary Antibody für WB - ABIN2668734
Sood, Balasubramanian, Higham, Fernando, Harrison: Osteoprotegerin (OPG) and related proteins (RANK, RANKL and TRAIL) in thyroid disease. in World journal of surgery 2011
Human Monoclonal TNFRSF11B Primary Antibody für ELISA, WB - ABIN2475981
Westheimer: Why nature chose phosphates. in Science (New York, N.Y.) 1987
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High OPG expression is associated with colorectal carcinoma.
Data suggest that elevated plasma levels of osteoprotegerin/TNFRSF11B correlate with increased risk of cardiovascular comorbidities in children and adolescents with type 1 diabetes (as compared to healthy control subjects); thus, osteoprotegerin/TNFRSF11B may serve as biomarker of cardiovascular risk in these patients. This study was conducted in Tunisia.
Studies showed that the central hypothalamic-pituitary regulatory system, via it's relative hormones, seems to control OPG/RANKL (zeige TNFSF11 Antikörper)/RANK system function, and the pulsatility and circadian rhythmicity of these hormones may induce an oscillatory fluctuation of the OPG/ RANKL (zeige TNFSF11 Antikörper) ratio. Also, psycological characteristics may provoke a shift of the OPG/ RANKL (zeige TNFSF11 Antikörper) ratio towards an unbalanced or a balanced status. [review]
Formulation and in vitro and in vivo evaluation of a new osteoprotegerin-chitosan gel for bone tissue regeneration
The RANKL/OPG (zeige TNFSF11 Antikörper) ratio significantly increased in the presence of bone metastasis with appropriate sensitivity and specificity (73% and 72%, respectively) at a cutoff of >/=0.14 for the detection of bone metastasis. Serum OPG and RANKL/OPG (zeige TNFSF11 Antikörper) ratios are promising biomarkers for detecting bone metastasis in breast cancer patients.
Osteoprotegerin facilitates pulmonary arterial hypertension pathogenesis by regulating pulmonary arterial smooth muscle cell proliferation via integrin alphavbeta3 (zeige ITGAV Antikörper)/FAK (zeige PTK2 Antikörper)/AKT (zeige AKT1 Antikörper) signaling pathway.
Elevated osteoprotegerin concentration is associated with an increased risk of incident cardiovascular disease in the general population
Physical activity does not increase circulating osteoprotegerin level.
OPG may be a potential driver of lung cancer cells and therefore might have potential in therapy and diagnostics.
our findings suggest OPG is a downstream effector of IL1B (zeige IL1B Antikörper)-mediated invasion in breast cancer cells.
findings demonstrate that mTORC1 activation-stimulated RANKL (zeige TNFSF11 Antikörper) expression in B cells is sufficient to induce bone loss and osteoporosis. The study also established a link between mTORC1 and the RANKL/OPG (zeige TNFSF11 Antikörper) axis via negative regulation of beta-catenin (zeige CTNNB1 Antikörper).
RANK/RANKL (zeige TNFSF11 Antikörper) signaling is involved in the androgen deprivation therapy-induced acceleration of bone metastasis in castration-insensitive prostate cancer and is inhibited by osteoprotegerin to prevent bone metastasis.
endocortical resorption is driven by reduced OPG (zeige TNFSF11 Antikörper) rather than elevated RANKL (zeige TNFSF11 Antikörper) expression
Diabetes significantly increased OPG (zeige TNFSF11 Antikörper) and the OPG (zeige TNFSF11 Antikörper)/TRAIL ratio expression in the aorta, while dyslipidemia was the major determinant of the changes observed in the heart, where it significantly increased OPG (zeige TNFSF11 Antikörper) and reduced TRAIL expression, thus increasing cardiac OPG (zeige TNFSF11 Antikörper)/TRAIL ratio.
These discoveries strongly suggest that Heparan Sulfate plays an active role in regulating OPG-RANKL (zeige TNFSF11 Antikörper) interaction and osteoclastogenesis.
OPG (zeige TNFSF11 Antikörper) plays an important role in regulating bone marrow mesenchymal stem cells differentiation and bone marrow adipogenesis.
These data suggested that OPG (zeige TNFSF11 Antikörper) played an important role in maintaining the homeostasis of articular cartilage of femoral head.
Data show that p38alpha (zeige MAPK14 Antikörper) mitogen-activated protein kinase (zeige MAPK1 Antikörper) (MAPK (zeige MAPK1 Antikörper)) in paired related homeobox 1 (zeige PRRX1 Antikörper) protein (Prx1 (zeige PRDX1 Antikörper)+) bone marrow-derived mesenchymal stromal cells acts to preserve the bone by sustaining osteoprotegerin (OPG) production.
OPG (zeige TNFSF11 Antikörper) expression in chondrocyte increases bone mass in the proximal metaphysis of tibiae through negative regulation of osteoclast formation.
the generation of Rag2GFP+ regulatory T cells is unaltered in Tnfrsf11b(-/-) mice
The OPG (zeige TNFSF11 Antikörper) expression levels decreased while those of RANKL (zeige TNFSF11 Antikörper) and RUNX2 (zeige RUNX2 Antikörper) increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.
Low-frequency vibration may promote the osteogenic differentiation capability of BMSC probably through regulating the OPG/RANKL (zeige TNFSF11 Antikörper) mRNA expression.
Regional variation of periosteal activity at the mandibular ramus is regulated by differential expression of osteoprotegerin.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
osteoclastogenesis inhibitory factor
, tumor necrosis factor receptor superfamily member 11B
, tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
, tumor necrosis factor receptor superfamily, member 11b
, tumor necrosis factor receptor superfamily member 11B-like