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TRIB2 encodes one of three members of the Tribbles family. Zusätzlich bieten wir Ihnen Tribbles Homolog 2 (Drosophila) Antikörper (68) und viele weitere Produktgruppen zu diesem Protein an.
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tissues expressing the highest levels of Xtrb2 were most markedly affected by morpholino knockdown, with perturbation of neural crest and eye development
Tumors from resistant patients expressed the lowest levels of TRIB2. Downregulation of TRIB2 contributes to platin-resistance.
our data show that excess p30 (zeige CENPV Proteine) cooperated with TRIB2 only in the presence of p42 (zeige EPB42 Proteine) to accelerate acute myeloid leukaemia (AML (zeige RUNX1 Proteine)), and the direct interaction and degradation of C/EBPa (zeige CEBPA Proteine) p42 (zeige EPB42 Proteine) is required for TRIB2-mediated AML (zeige RUNX1 Proteine).
miR (zeige MLXIP Proteine)-206 and miR (zeige MLXIP Proteine)-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3 (zeige SMAD3 Proteine).
Studied effect of TRIB2 SNP on the expression of genes involved in adaptive thermogenesis using messenger RNAs prepared from adipose tissues of Japanese adults. Of the five thermogenic genes, DIO2 (zeige DIO2 Proteine), CIDEA (zeige CIDEA Proteine), PPARGC1A, and PRDM16 (zeige PRDM16 Proteine) showed significantly higher transcript levels in SAT of individuals with the AA genotype relative to those with the AT + TT genotype.
Data show that TRIB2-mediated degradation of CDC25C (zeige CDC25C Proteine) is associated with lysine-48-linked CDC25C (zeige CDC25C Proteine) polyubiquitination driven by the TRIB2 kinase-like domain.
High TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 (zeige TAL1 Proteine) complex in T-cell acute lymphoblastic leukemia.
Studies suggest that pseudo-kinase family of tribbles (zeige TRIB1 Proteine) (TRIB) proteins TRIB1 (zeige TRIB1 Proteine), TRIB2 and TRIB3 (zeige TRIB3 Proteine) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies suggest that pseudo-kinase family of tribbles (zeige TRIB1 Proteine) (TRIB) proteins TRIB1 (zeige TRIB1 Proteine), TRIB2 and TRIB3 (zeige TRIB3 Proteine) were involved in the pathogenesis of inflammation.
Studies suggest that tribbles homolog 2 (Drosophila) protein (TRIB2) as a meaningful biomarker to both diagnose and stage melanoma.
Studies indicate that the molecular interactions that take place between tribbles homolog 2 (Drosophila) protein (TRIB2) and factors involved in the ubiquitin proteasome system (UPS) are varied and have differential downstream effects.
The absence of a change in hypocretin cell populations suggested that factors other than anti-TRIB2 antibody play a part in the loss of hypocretin neurons in narcolepsy. The increased anti-TRIB2 antibody after the destruction of hypocretin neurons suggest that anti-TRIB2 antibody in narcolepsy patients is the consequence rather than the inciting cause of hypocretin cell destruction.
These data indicate that Trib2 has a complex role in the pathogenesis of Notch (zeige NOTCH1 Proteine)-driven T-ALL, which may vary between different T-ALL subtypes.
TRIB1 (zeige TRIB1 Proteine) and TRIB3 (zeige TRIB3 Proteine) are more strongly expressed than TRIB2 in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
we identify the contribution of dysregulated C/EBPalpha (zeige CEBPA Proteine) and E2F1 (zeige E2F1 Proteine) to elevated Trib2 expression and leukemic cell survival
Trib2 transduced hematopoietic stem cells developed acute myeloid leukemia (zeige BCL11A Proteine).
Elevated Tribbles homolog 2-specific antibody levels in narcolepsy patients.
Data identify Tribbles homolog 2 as an oncogene (zeige RAB1A Proteine) that induces acute myelogenous leukemia through a mechanism involving inactivation of C/EBPalpha (zeige CEBPA Proteine).
describe suppression of adipocyte differentiation by TRBs Trib1 (zeige TRIB1 Proteine), Trib2, Trib3 (zeige TRIB3 Proteine)
Mice reconstituted with HSC (zeige FUT1 Proteine) cotransduced with HoxA9 (zeige HOXA9 Proteine) and Trib2 had accelerated onset of AML (zeige RUNX1 Proteine) compared to either gene alone
Linkage of Meis1 (zeige MEIS1 Proteine) leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3 (zeige CCL3 Proteine).
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
tribbles homolog 2 (Drosophila)
, tribbles homolog 2-like
, tribbles homolog 2
, serine/threonine protein kinase
, tribbles-like protein 2