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Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein Proteine (TRPC4AP)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. Zusätzlich bieten wir Ihnen Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein Antikörper (55) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TRPC4AP 56407 Q9JLV2
TRPC4AP 26133 Q8TEL6
Ratte TRPC4AP TRPC4AP 362247  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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TRPC4AP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) Interaktionspartnern

Mouse (Murine) Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) Interaktionspartner

  1. cloning and characterization of tumor necrosis factor receptor 1 (TNF-R1 (zeige TNFRSF1A Proteine))-associated ubiquitous scaffolding and signaling protein (TRUSS)

Human Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) Interaktionspartner

  1. TRUSS is a novel substrate of E3 ligase Skp2.

  2. The latent classification method of analysis showed that the TRPC4AP H1 haplotype was characteristic of Alzheimer's patients, with ages-of-onset between 66 and 80 years.

  3. These findings suggest that TNF-R1 (zeige TNFRSF1A Proteine), TRUSS, and TRPC4 (zeige TRPC4 Proteine) augment Ca(2 (zeige CA2 Proteine)+) loading of endoplasmic reticulum Ca(2 (zeige CA2 Proteine)+) stores in the context of m1AchR stimulation

  4. TRPC4AP/TRUSS binds specifically to the Myc (zeige MYC Proteine) C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc (zeige MYC Proteine) N terminus

  5. results suggest that TRPC4AP is involved with the disease in these late-onset Alzheimer's families

Transient Receptor Potential Cation Channel, Subfamily C, Member 4 Associated Protein (TRPC4AP) Protein Überblick

Protein Überblick

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1.

Genbezeichner und Symbole assoziert mit TRPC4AP

  • transient receptor potential cation channel, subfamily C, member 4 associated protein (TRPC4AP)
  • transient receptor potential cation channel, subfamily C, member 4 associated protein (trpc4ap)
  • transient receptor potential cation channel, subfamily C, member 4 associated protein (Trpc4ap)
  • 4833429F06Rik Protein
  • C20orf188 Protein
  • D2Ertd113e Protein
  • mFLJ00177 Protein
  • MGC130977 Protein
  • TRPC4AP Protein
  • TRRP4AP Protein
  • TRUSS Protein

Bezeichner auf Proteinebene für TRPC4AP

short transient receptor potential channel 4-associated protein , transient receptor potential cation channel, subfamily C, member 4 associated protein , TRPC4-associated protein , TRPC4-associated protein-like , short transient receptor potential channel 4-associated protein-like , TNF-receptor ubiquitous scaffolding/signaling protein , Trp4-associated protein TAP1 , rabex-5/Rin2-interacting protein , transient receptor protein 4, associated protein , trpc4-associated protein , TRP4-associated protein , short transient receptor potential channel 4 associated protein , tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein

GENE ID SPEZIES
428134 Gallus gallus
458196 Pan troglodytes
532834 Bos taurus
712164 Macaca mulatta
734909 Xenopus laevis
100145210 Xenopus (Silurana) tropicalis
100345322 Oryctolagus cuniculus
100449842 Pongo abelii
100543270 Meleagris gallopavo
100561242 Anolis carolinensis
100069434 Equus caballus
100396278 Callithrix jacchus
100469662 Ailuropoda melanoleuca
56407 Mus musculus
26133 Homo sapiens
477207 Canis lupus familiaris
362247 Rattus norvegicus
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