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Transglutaminase 1, Keratinocyte Proteine (TGM1)

The protein encoded by TGM1 is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. Zusätzlich bieten wir Ihnen TGM1 Antikörper (70) und TGM1 Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TGM1 7051 P22735
TGM1 60335 P23606
TGM1 21816 Q9JLF6
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Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
670,48 €
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HOST_Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
680,00 €
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HOST_Escherichia coli (E. coli) Ratte His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
700,95 €
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HOST_Escherichia coli (E. coli) Kaninchen His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
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HOST_Escherichia coli (E. coli) Hund His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
734,29 €
Details
HOST_Wheat germ Human GST tag   10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 5 bis 7 Tage
324,01 €
Details

TGM1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

Am meisten referenzierte TGM1 Proteine

  1. Human TGM1 Protein expressed in Wheat germ - ABIN1322632 : Yang, Chevolot, Géhin, Solassol, Mange, Souteyrand, Laurenceau: Improvement of protein immobilization for the elaboration of tumor-associated antigen microarrays: application to the sensitive and specific detection of tumor markers from breast cancer sera. in Biosensors & bioelectronics 2012 (PubMed)

Weitere Proteine zu Transglutaminase 1, Keratinocyte (TGM1) Interaktionspartnern

Human Transglutaminase 1, Keratinocyte (TGM1) Interaktionspartner

  1. Seven of 10 probands with a compound heterozygous TGM1 genotype had a mutation at either arginine 307 or 315, providing evidence that mutations at these sites are temperature sensitive and highlighting the importance of these residues in the pathogenesis of bathing suit ichthyosis (zeige LBR Proteine)

  2. The results strongly supported the participation of TGM1 in the regulation of gastric cancer development. The authors found evidence that the mechanism of action of TGM1 in regulating gastric cancer cell might involve the Wnt (zeige WNT2 Proteine) signaling pathway, as loss of TGM1 expression in gastric cancer cells led to a significant suppression of Wnt (zeige WNT2 Proteine) signaling activities.

  3. we identified three novel mutations and one reported mutation in the TGM1 and ABCA12 genes, respectively, in affected siblings of five Saudi unrelated families.

  4. Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 (zeige TGM2 Proteine) mRNA levels by 2.9 fold.

  5. In summary, we have identified three novel sequence variants, one in TGM1 and two in ALOXE3 (zeige ALOXE3 Proteine), in three consanguineous families segregating lamellar ichthyosis (zeige LBR Proteine) and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis (zeige LBR Proteine).

  6. Our results thus indicated that the TGM1 mutation affects the formation of corni fi ed cell envelope by multiple mechanisms and leads to an almost identical clinical phenotype of generalized erythema and scales.

  7. Two siblings with autosomal recessive congenital ichthyosis (zeige LBR Proteine), were found to carry a novel aetiological TGM1 mutation that leads to the synthesis of multiple abnormal transcripts.

  8. mRNA expression of transglutaminase 1 and transglutaminase 3 (zeige TGM3 Proteine) was significantly decreased in patients with chronic periodontitis compared with a healthy control group.

  9. In this study, we found that 14 different TGM1 mutations have been identified and reported in 13 individuals with ARCI from 8 families with congental ichthyosis (zeige LBR Proteine), comprising 9 missense mutations, 1 deletion and 1 splice-site mutation .

  10. Structure-function implication on a novel homozygous Trp250/Gly mutation of transglutaminase-1 (TGM1) observed in a patient of autosomal recessive congenital ichthyosis (zeige LBR Proteine) is invoked from a bioinformatics analysis.

Cow (Bovine) Transglutaminase 1, Keratinocyte (TGM1) Interaktionspartner

  1. Linkage analysis excluded TGM1 as the cause for ichthyosis (zeige LBR Proteine) phenotype.

Mouse (Murine) Transglutaminase 1, Keratinocyte (TGM1) Interaktionspartner

  1. This study investigated the in situ activities of transglutaminase-1 (skin-type) and transglutaminase-2 (zeige TGM2 Proteine) (tissue-type) using whole mouse sections of various embryonic developmental stages and neonates.

  2. The R142C mutation of transglutaminase 1 reduces the enzyme stability which is indispensable for development of the stratum corneum and skin barrier function and for postnatal survival of mice.

  3. Molecular deletion of transglutaminase 2 (zeige TGM2 Proteine) alone is insufficient to protect Mus (zeige TRPV6 Proteine) musculus neurons from oxidative death, but inhibition of transglutaminase 1 and 2 is neuroprotective.

  4. These studies demonstrate that tranglutaminase 2 independent activity exists in the vasculature and that Tgm1 and tgm4 (zeige TGM4 Proteine) are expressed in vascular tissues

  5. Mouse models are used to study the role of tissue transglutaminase (tTG (zeige TGM2 Proteine))in Huntington's disease; its critical that the level of expression in mouse forebrain be determined. tTG (zeige TGM2 Proteine) contributes to the majority of transglutaminase activity in mouse forebrain.

  6. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

  7. Tissue-specific stabilization of the cortical actin filament network by intracellular TGase1 activity may play a role in controlling barrier properties of endothelial monolayers

  8. transglutaminase 1

  9. Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation

  10. results demonstrate that TGase-1 plays an important role in regulation of renal epithelial cell proliferation through the JAK2 (zeige JAK2 Proteine)-Stat-3 (zeige STAT3 Proteine) signaling pathway

TGM1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).

Genbezeichner und Symbole assoziert mit TGM1

  • transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) (TGM1)
  • transglutaminase 1 like 4 (tgm1l4)
  • transglutaminase 1 (TGM1)
  • transglutaminase 1 (Tgm1)
  • transglutaminase 1, K polypeptide (Tgm1)
  • 2310004J08Rik Protein
  • ARCI1 Protein
  • fa12g12 Protein
  • ICR2 Protein
  • KTG Protein
  • LI Protein
  • LI1 Protein
  • TGASE Protein
  • Tgase1 Protein
  • TGK Protein
  • TGM1 Protein
  • wu:fa12g12 Protein
  • zgc:112355 Protein

Bezeichner auf Proteinebene für TGM1

transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) , TG1-62 , transglutaminase 1 , K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase , TG(K) , TGase K , TGase-1 , epidermal TGase , protein-glutamine gamma-glutamyltransferase K , transglutaminase 1 isoform , transglutaminase K , transglutaminase, keratinocyte , transglutaminase-1 , TGK , transglutaminase 1, K polypeptide , Protein-glutamine gamma-glutamyltransferase K , tranglutaminase 1 , K polypeptide , TG K , TGase 1 , protein-glutamine-gamma-glutamyltransferase , transglutaminase type 1

GENE ID SPEZIES
452814 Pan troglodytes
555962 Danio rerio
7051 Homo sapiens
60335 Rattus norvegicus
100724400 Cavia porcellus
100009118 Oryctolagus cuniculus
403630 Canis lupus familiaris
407997 Bos taurus
21816 Mus musculus
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