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The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. Zusätzlich bieten wir Ihnen TFE3 Antikörper (101) und TFE3 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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results reveal that PRCC (zeige PRCC Proteine)-TFE3 dual-fusion FISH probe is an efficient and concise technique for diagnosing PRCC (zeige PRCC Proteine)-TFE3 RCC (zeige XRCC1 Proteine) in paraffin-embedded tissue
Case Report: Melanotic Xp11 renal cell carcinoma (zeige MOK Proteine) with ARID1B-TFE3 gene fusion.
Studies identified TFEB (zeige TFEB Proteine) and TFE3 as master modulators of stress response notably in the lysosomal biogenesis and autophagy with capability to upregulate hundreds of genes involved in intracellular clearance, catabolism, metabolic processes, and cellular homeostasis.
Ovarian sclerosing stromal tumor strongly overexpress TFE3.
Describe the unusual morphology and expanded the morphologic spectrum of SFPQ/PSF-TFE3 renal cell carcinomas.
Despite TFE3 over expression, TFE3 genetic alterations are less likely to be a major molecular event driving tumorigenesis in hepatic angiolipomas.
we analyze 60 Xp11 translocation cancers by fluorescence in situ hybridization using custom bacterial artificial chromosome probes to establish their TFE3 fusion gene partner
These results show that ASPL (zeige ASPSCR1 Proteine)-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 (zeige CDKN1A Proteine) expression.
RBM10 (zeige RBM10 Proteine)-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma (zeige MOK Proteine).
Case Report: melanotic PEComa of the sinonasal mucosa with NONO (zeige NONO Proteine)-TFE3 fusion.
Tfe3 and Tfeb (zeige TFEB Proteine) are required for the induced expression of Ppargamma2 (zeige PPARG Proteine) and subsequently for adipogenic genes.
Tfe3 overexpression in HSPCs impaired long-term hematopoietic reconstitution in vivo, recapitulating the Flcn (zeige FLCN Proteine) KO phenotype, and supporting the notion that abnormal activation of Tfe3 contributes to the Flcn (zeige FLCN Proteine) KO phenotype. Flcn (zeige FLCN Proteine) KO mice develop an acute histiocytic hyperplasia in multiple organs, suggesting a novel function for Flcn (zeige FLCN Proteine) in macrophage development
TFEB (zeige TFEB Proteine) and TFE3 are novel components of the integrated stress response
Tfe3 is a critical transcription factor that regulates Pgc-1alpha gene expression in myotubes
A conditional expression in mice of the fusion gene ASPSCR1 (zeige ASPSCR1 Proteine)-TFE3 from human alveolar soft part sarcoma (ASPS (zeige DARS Proteine)) generated a model that recapitulates the human tumor histologically and by expression profile.
Data from transgenic mice suggest Tfe3 controls lipid metabolism in adipose tissue (white, WAT; brown, BAT (zeige BAAT Proteine)); TFE3 appears to be regulated by diet; up-regulation of TFE3 may inhibit expression of lipolysis genes in WAT and thermogenesis genes in BAT (zeige BAAT Proteine).
These findings indicated that TFE3 has a regulatory role in myoblast differentiation, and that transcriptional suppression of myogenin (zeige MYOG Proteine) expression may be part of the mechanism of action.
Machinery regulating exit of embryonic stem cells from pluripotency is ill defined; Flcn (zeige FLCN Proteine) with its interaction partners Fnip1 and Fnip2 (zeige FNIP2 Proteine) drives differentiation by restricting nuclear localization and activity of the bHLH transcription factor (zeige MSGN1 Proteine) Tfe3.
TFE3 and Galpha (zeige SUCLG1 Proteine)(16) are up-regulated under pathologic conditions and are involved in a novel mechanism of transcriptional regulation via the relocalization and activation of Galpha (zeige SUCLG1 Proteine)(16).
FLCN (zeige FLCN Proteine) tumor suppressor gene inactivation induces TFE3 transcriptional activity by increasing its nuclear localization
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.
class E basic helix-loop-helix protein 33
, transcription factor E family, member A
, transcription factor E3
, transcription factor for IgH enhancer
, transcription factor for immunoglobulin heavy-chain enhancer 3