Thymopoietin Proteine (TMPO)

The protein encoded by TMPO resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. Zusätzlich bieten wir Ihnen Thymopoietin Antikörper (112) und Thymopoietin Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte TMPO TMPO 25359 Q62733
TMPO 7112 P42166 , P42167
TMPO 21917 Q61033 , Q61029
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Showing 9 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
HOST_Escherichia coli (E. coli) Human His tag Human TMPO, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 9 bis 10 Tage
360,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
392,86 €
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
328,90 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
214,29 €
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
1.920,64 €
Details
HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
588,57 €
Details

TMPO Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,

Weitere Proteine zu Thymopoietin (TMPO) Interaktionspartnern

Human Thymopoietin (TMPO) Interaktionspartner

  1. Study found TMPO is significantly upregulated in glioblastoma tissues.TMPO knockdown promoted cell apoptosis by upregulation of the cleavage of caspase-3 (zeige CASP3 Proteine) and PARP protein levels.

  2. The findings unveil a unique mechanism where the nuclear periphery proteins lamin-A/C (zeige LMNA Proteine), LAP2alpha and BAF1 are assembled into a protein complex during mitosis in order to regulate assembly and positioning of the mitotic spindle.

  3. The authors find that LAP2alpha (lamina-associated polypeptide-alpha) interacts with lamin A (zeige LMNA Proteine), while its interaction with progerin is significantly reduced.

  4. Results highlight the interactions at the nuclear envelope where mutations in the EMD (zeige EMD Proteine) and TMPO gene in combination with mutations in SUN1 (zeige SUN1 Proteine) have an impact on several components of the network.

  5. Data indicate that cells lacking either high mobility group (zeige SSRP1 Proteine) protein N5 (HMGN5 (zeige HMGN5 Proteine)) and lamina-associated polypeptide 2alpha (LAP2alpha) showed that loss of either protein affects the genome-wide distribution of the remaining partner.

  6. this study provides evidence for elevated LAP2alpha expression in cervical cancer and suggests that E2F (zeige E2F1 Proteine) and p53 (zeige TP53 Proteine) activities associate with the positive and negative regulation of LAP2alpha expression, respectively

  7. data suggest that hypophosphorylated Rb is anchored in the nucleus by the interaction of pocket C with LAP2alpha-lamin A/C (zeige LMNA Proteine) complexes

  8. Results indicate that in vitro, the interaction between HA95 (zeige AKAP8L Proteine) and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 (zeige AKAP8L Proteine) rather than by CDK1 (zeige CDK1 Proteine)- or PKC (zeige PRRT2 Proteine)-mediated phosphorylation of LAP2beta

  9. LAP2alpha and BAF (zeige BANF1 Proteine) transiently localize to telomeres and specific regions on chromatin during nuclear assembly

  10. A predicted Arg690Cys substitution within the LAP2 (zeige ERBB2IP Proteine) gene is implicated in the pathogenesis of genetic forms of dilated cardiomyopathy.

Cow (Bovine) Thymopoietin (TMPO) Interaktionspartner

  1. Lamin (zeige LMNA Proteine)-associated polypeptide (LAP)2 beta assembles around only alternative oocyte chromatin after complete dephosphorylation of histone H3 (zeige HIST3H3 Proteine) following fertilization and activation. (lamina-associated polypeptide 2; LAP2beta)

Mouse (Murine) Thymopoietin (TMPO) Interaktionspartner

  1. Lifespan and body mass were increased in Lmna (zeige LMNA Proteine)(-/-)Lap2alpha(-/-) mice compared with Lmna (zeige LMNA Proteine) deficient mice.

  2. Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C (zeige LMNA Proteine) is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C (zeige LMNA Proteine) in the regulation of tissue progenitor cells are not affected in Lmna (zeige LMNA Proteine)(DeltaK32/DeltaK32) mice.

  3. LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific (zeige EIF3K Proteine) gene expression during muscle regeneration, muscle remodeling and stress response.

  4. TSLP (zeige TSLP Proteine) diverts airway tolerance against ovalbumin (zeige OVA Proteine) (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.

  5. The age-related down-regulation of Wnt4 (zeige WNT4 Proteine) (and subsequently FoxN1 (zeige FOXN2 Proteine)), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.

  6. Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.

  7. Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 (zeige GATA4 Proteine) and MEF2c (zeige MEF2C Proteine), while dstrophin deficiency in Mdx (zeige DMD Proteine) mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.

  8. In agreement with its regulation by E2F (zeige E2F1 Proteine), LAP2alpha over expression in primary tumors was found to be correlated with tumor proliferation rate

  9. Loss of LAP2-Lmna (zeige LMNA Proteine) complexes causes erythroid and epidermal progenitor hyperproliferation.

Thymopoietin (TMPO) Protein Überblick

Protein Überblick

The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Genbezeichner und Symbole assoziert mit Thymopoietin Proteine (TMPO)

  • thymopoietin (TMPO)
  • thymopoietin (Tmpo)
  • thymopoietin (tmpo)
  • thymopoietin a (tmpoa)
  • 5630400D24Rik Protein
  • AI195756 Protein
  • AI606875 Protein
  • AW214352 Protein
  • AW547477 Protein
  • CMD1T Protein
  • lap2 Protein
  • LAP2beta Protein
  • LEMD4 Protein
  • PRO0868 Protein
  • tmpo Protein
  • TP Protein
  • wu:fc26f12 Protein
  • wu:fd21f02 Protein
  • wu:fi29h05 Protein

Bezeichner auf Proteinebene für Thymopoietin Proteine (TMPO)

thymopoietin , lamina-associated polypeptide 2, isoform alpha-like , TP beta , Thymopoietin (lamina associated polypeptide 2) , lamina-associated polypeptide 2 , thymopoietin isoform beta , LEM domain containing 4 , TP alpha , TP beta/gamma , thymopoietin-related peptide isoform alpha , thymopoietin-related peptide isoforms beta/gamma , lamina associated polypeptide 2 , lamin-associated polypeptide 2beta , thymopoietin II , thymopoietin-2 , etID53005.4 , lamina-associated protein 2

GENE ID SPEZIES
452151 Pan troglodytes
693387 Macaca mulatta
100387152 Callithrix jacchus
100457982 Pongo abelii
100588465 Nomascus leucogenys
25359 Rattus norvegicus
7112 Homo sapiens
397975 Xenopus laevis
417923 Gallus gallus
482618 Canis lupus familiaris
510267 Bos taurus
21917 Mus musculus
352907 Danio rerio
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