Thymocyte Selection Associated (THEMIS) ELISA Kits

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Zusätzlich bieten wir Ihnen THEMIS Antikörper (92) und THEMIS Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Human THEMIS THEMIS 387357 Q8N1K5
Anti-Maus THEMIS THEMIS 210757 Q8BGW0
THEMIS 540554 A5D789
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Weitere ELISA Kits für THEMIS Interaktionspartner

Human Thymocyte Selection Associated (THEMIS) Interaktionspartner

  1. we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4 (zeige CD4 ELISA Kits)+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms

  2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  5. THEMIS binding to GRB2 (zeige GRB2 ELISA Kits) was required for thymocyte development.

  6. SPOP (zeige SPOP ELISA Kits) mutations may define a new molecular subtype of prostate cancer.

  7. specific role for THEMIS in early TCR signalosome function

  8. Functional characterization of the homologous mouse gene.

  9. Functional analysis of the mouse gene by knockout, and comparison of the mouse a (zeige PTCRA ELISA Kits)nd human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) Interaktionspartner

  1. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  2. The results demonstrate an essential requirement for the PRR (zeige PVRL1 ELISA Kits) and NLS (zeige ALDH1A2 ELISA Kits) motifs but not the conserved CABIT cysteines for Themis1 function.

  3. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  4. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  5. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  6. specific role for THEMIS in early TCR signalosome function

  7. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  8. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  9. Themis had high expression in thymocytes between the pre-T cell antigen receptor (zeige PTCRA ELISA Kits) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

  10. Gasp (zeige GPRASP1 ELISA Kits) associates with Grb2 (zeige GRB2 ELISA Kits) and is required for positive selection of thymocytes

THEMIS Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit THEMIS

  • thymocyte selection associated (THEMIS) Antikörper
  • thymocyte selection associated (Themis) Antikörper
  • thymocyte selection associated (themis) Antikörper
  • A430108D01 Antikörper
  • bA325O24.3 Antikörper
  • bA325O24.4 Antikörper
  • BB160712 Antikörper
  • C6orf190 Antikörper
  • C6orf207 Antikörper
  • C9H6ORF190 Antikörper
  • E430004N04Rik Antikörper
  • Gasp Antikörper
  • im:7138580 Antikörper
  • SPOT Antikörper
  • thylex Antikörper
  • tsepa Antikörper

Bezeichner auf Proteinebene für THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPEZIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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