anti-Thymocyte Selection Associated (THEMIS) Antikörper

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Zusätzlich bieten wir Ihnen THEMIS Proteine (4) und THEMIS Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
THEMIS 387357 Q8N1K5
THEMIS 210757 Q8BGW0
THEMIS    
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Top anti-THEMIS Antikörper auf antikoerper-online.de

Showing 10 out of 91 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB THEMIS Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human thymoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of THEMIS Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. THEMIS Antibody (C-term) western blot analysis in mouse liver tissue lysates (35 µg/lane). This demonstrates the THEMIS antibody detected the THEMIS protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Maus Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
722,86 €
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: Themis Antibody  - Analysis in human cell line Jurkat. Immunohistochemistry-Paraffin: Themis Antibody  - Staining of human tonsil shows strong granular cytoplasmic positivity in germinal center cells and non-germinal center cells. 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
Details
Maus Kaninchen Unkonjugiert IHC (p), WB THEMIS Antibody (C-term) (ABIN655135) immunohistochemistry analysis in formalin fixed and paraffin embedded human thymoma followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Unkonjugiert CyTOF, FACS Detection of Themis in Human Blood Lymphocytes by Flow Cytometry Human peripheral blood lymphocytes were stained with Mouse Anti-Human Themis Monoclonal Antibody. Detection of Themis in Human Blood Lymphocytes by Flow Cytometry Human peripheral blood lymphocytes were stained with Mouse Anti-Human Themis Monoclonal Antibody. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
255,00 €
Details
Maus Ratte Unkonjugiert CyTOF, FACS, WB Detection of Themis in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with Rat Anti-Mouse Themis Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. Detection of Mouse Themis by Western Blot. Western blot shows lysates of mouse thymus tissue. PVDF membrane was probed with 1 ug/mL of Rat Anti-Mouse Themis Monoclonal Antibody. This experiment was conducted under reducing conditions. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
255,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney tissue labeled with Anti-THEMIS Polyclonal Antibody, Unconjugated 1:400 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human kidney tissue labeled with Anti-THEMIS Polyclonal Antibody, Unconjugated 1:400 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 18 bis 22 Tage
304,36 €
Details
Maus Ratte PE FACS Detection of Themis in Mouse Thymocytes by Flow Cytometry. Mouse thymocytes were stained with Rat Anti-Mouse Themis PE-conjugated Monoclonal Antibody. 100 Tests Anmelden zum Anzeigen 3 bis 4 Tage
300,00 €
Details
Maus Ziege Unkonjugiert ELISA, WB   0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details

THEMIS Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-THEMIS Antikörper

  1. Human Monoclonal THEMIS Primary Antibody für WB - ABIN2689927 : Fu, Vallée, Rybakin, McGuire, Ampudia, Brockmeyer, Salek, Fallen, Hoerter, Munshi, Huang, Hu, Fox, Sauer, Acuto, Gascoigne: Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. in Nature immunology 2009 (PubMed)
    Show all 4 Pubmed References

  2. Mouse (Murine) Polyclonal THEMIS Primary Antibody für ELISA, WB - ABIN4359167 : Lesourne, Uehara, Lee, Song, Li, Pinkhasov, Zhang, Weng, Wildt, Wang, Bosselut, Love: Themis, a T cell-specific protein important for late thymocyte development. in Nature immunology 2009 (PubMed)

  3. Human Polyclonal THEMIS Primary Antibody für IHC, IHC (p) - ABIN4359153 : Paster, Bruger, Katsch, Grégoire, Roncagalli, Fu, Gascoigne, Nika, Cohnen, Feller, Simister, Molder, Cordoba, Dushek, Malissen, Acuto: A THEMIS:SHP1 complex promotes T-cell survival. in The EMBO journal 2015 (PubMed)

Weitere Antikörper gegen THEMIS Interaktionspartner

Human Thymocyte Selection Associated (THEMIS) Interaktionspartner

  1. we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4 (zeige CD4 Antikörper)+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms

  2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  5. THEMIS binding to GRB2 (zeige GRB2 Antikörper) was required for thymocyte development.

  6. SPOP (zeige SPOP Antikörper) mutations may define a new molecular subtype of prostate cancer.

  7. specific role for THEMIS in early TCR signalosome function

  8. Functional characterization of the homologous mouse gene.

  9. Functional analysis of the mouse gene by knockout, and comparison of the mouse a (zeige PTCRA Antikörper)nd human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) Interaktionspartner

  1. the positive selection of immature CD4 (zeige CD4 Antikörper)+CD8 (zeige CD8A Antikörper)+ double-positive thymocytes and their commitment to the CD4 (zeige CD4 Antikörper)+CD8 (zeige CD8A Antikörper)- single-positive stage are impaired in Themis-/- mice

  2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  3. The results demonstrate an essential requirement for the PRR (zeige PVRL1 Antikörper) and NLS (zeige ALDH1A2 Antikörper) motifs but not the conserved CABIT cysteines for Themis1 function.

  4. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  5. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  6. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  7. specific role for THEMIS in early TCR signalosome function

  8. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  9. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  10. Themis had high expression in thymocytes between the pre-T cell antigen receptor (zeige PTCRA Antikörper) and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

THEMIS Antigen-Profil

Protein Überblick

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit THEMIS

  • thymocyte selection associated (THEMIS) Antikörper
  • thymocyte selection associated (Themis) Antikörper
  • thymocyte selection associated (themis) Antikörper
  • A430108D01 Antikörper
  • bA325O24.3 Antikörper
  • bA325O24.4 Antikörper
  • BB160712 Antikörper
  • C6orf190 Antikörper
  • C6orf207 Antikörper
  • C9H6ORF190 Antikörper
  • E430004N04Rik Antikörper
  • Gasp Antikörper
  • im:7138580 Antikörper
  • SPOT Antikörper
  • thylex Antikörper
  • tsepa Antikörper

Bezeichner auf Proteinebene für THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPEZIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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