TIMP Metallopeptidase Inhibitor 3 Proteine (TIMP3)

TIMP3 belongs to the TIMP gene family. Zusätzlich bieten wir Ihnen TIMP3 Antikörper (190) und TIMP3 Kits (106) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIMP3 7078 P35625
TIMP3 25358  
TIMP3 21859 P39876
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Showing 10 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Rind (Kuh) His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
789,52 €
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HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.222,70 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.332,70 €
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.332,70 €
Details

TIMP3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus) ,

Mouse (Murine) ,

Weitere Proteine zu TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartnern

Human TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. Electrostatic potential calculations suggested a competition between negatively charged GAGs and highly negatively charged complement-like domains of LRP-1 (zeige LRP1 Proteine) for the binding to a positively charged area of TIMP-3 as an underlying mechanism.

  2. TIMP3 overexpression after myocardial infarction improves myocardial structural remodeling and function by promoting angiogenesis and inhibiting early proteolysis.

  3. Single Nucleotide Variants of Candidate Genes in Aggrecan (zeige ACAN Proteine) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes

  4. Our data suggest that miR (zeige MLXIP Proteine)-206 may function as an inflammatory regulator and drive the expression of MMP9 (zeige MMP9 Proteine) in M.tb-infected THP-1 cells by targeting TIMP3, indicating that miR (zeige MLXIP Proteine)-206 is a potential therapeutic target for patients with TB.

  5. Plasma TIMP3 is a biomarker for predicting the tumor stage in patients with oral squamous cell carcinoma .

  6. TIMP-3 K26A/K45A retained higher affinity for sulfated (zeige SULF1 Proteine) glycosaminoglycans than K42A/K110A and exhibited increased affinity for ADAMTS-5 (zeige ADAMTS5 Proteine) in the presence of heparin.

  7. Of the 225 genetic tests performed, 150 were for recessive IRD, and 75 were for dominant IRD. A positive molecular diagnosis was made in 70 (59%) of probands with recessive IRD and 19 (26%) probands with dominant IRD. Thirty-two novel variants were identified; among these, 17 sequence changes in four genes were predicted to be possibly or probably damaging including: ABCA4 (zeige ABCA4 Proteine) (14), BEST1 (zeige BEST1 Proteine) (2), PRPH2 (zeige PRPH2 Proteine) (1), and TIMP3

  8. Study evaluated MMP-12 (zeige MMP12 Proteine) and TIMP-1 (zeige TIMP1 Proteine), TIMP-2 (zeige TIMP2 Proteine), TIMP-3, and TIMP-4 (zeige TIMP4 Proteine) levels in 40 patients with asymptomatic and symptomatic critical carotid artery stenosis (CAS (zeige CSE1L Proteine)) with neurologic symptoms onset within the preceding 12 hours; results suggest that MMP-12 (zeige MMP12 Proteine) is related to critical CAS (zeige CSE1L Proteine) independently on symptoms, moreover, TIMP-3 and TIMP-4 (zeige TIMP4 Proteine) seem to be specifically related to stroke

  9. A total of 1096 subjects from eight studies were included in the present meta-analysis. Overall, a significant association between TIMP-3 methylation and gastric cancer risk was observed (OR = 8.65; 95% CI4.31-17.37; p < 0.001). Our results show a positive correlation between TIMP-3 promoter methylation and gastric cancer risk and that TIMP-3 promoter methylation may be used as a molecular marker for gastric cancer

  10. TIMP-3 expression is suppressed by promoter methylation in HCC (zeige FAM126A Proteine).

Rabbit TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 (zeige MMP1 Proteine) and decreased TIMP-3 secretion.

  2. TIMP-3 is downregulated in a distinct subpopulation of atherosclerotic foam cells which have increased MMP-14 (zeige MMP14 Proteine).

Cow (Bovine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. Reactive oxygen species mediate TGF-beta1 (zeige TGFB1 Proteine)-induced TIMP-3 gene expression

  2. TIMP3 has a role in the pericyte-induced stabilization of newly formed vascular networks that are predisposed to undergo regression and reveal specific molecular targets of the inhibitors regulating these events.

  3. TIMP3 mRNA expression level was upregulated by multidirectional articular motion.

Xenopus laevis TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. only the N-terminal, but not the C-terminal domain of TIMP-3, results in developmental defects.

  2. metamorphic tail and intestine RNA levels of TIMP-2 (zeige TIMP2 Proteine), MT1-MMP (zeige MMP14 Proteine) and Gel-A, but not MT3-MMP (zeige MMP24 Proteine) or TIMP-3, are elevated during periods of cell death and proliferation

Mouse (Murine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. TIMP3 promotes normal microvascular endothelial cell barrier function, at least partially, through inhibition of metalloproteinase-dependent disruption of adherens junctions, and septic downregulation of TIMP3 may contribute to septic MVEC barrier dysfunction.

  2. data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI (zeige TBPL1 PLURAL_@42429@), an area with few if any therapeutic options.

  3. Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions.

  4. 4-Hydroxyisoleucine improved insulin (zeige INS Proteine) resistant-like state in 3T3-L1 adipocytes by targeting TACE (zeige ADAM17 Proteine)/TIMP3 and the insulin (zeige INS Proteine) signaling pathway.

  5. In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors.

  6. Timp3 status determines p53 (zeige TP53 Proteine), p38 (zeige CRK Proteine) and Notch (zeige NOTCH1 Proteine) coactivation to instruct hepatic cell fate and transformation.

  7. TIMP2 (zeige TIMP2 Proteine) and TIMP3 play fundamental and differential roles in mediating pathological remodelling, independent from their MMP-inhibitory function

  8. Expansion of stem cells counteracts age-related mammary regression in compound Timp1 (zeige TIMP1 Proteine)/Timp3-deficient mice.

  9. lack of TIMP3 increases inflammation and polarizes macrophages towards a more inflammatory phenotype resulting in increased atherosclerosis.

  10. TIMP-3 KO mice exhibit enhanced metabolism, as reflected by a higher body temperature than WT mice, possibly due to increased mitochondrial activity.

Pig (Porcine) TIMP Metallopeptidase Inhibitor 3 (TIMP3) Interaktionspartner

  1. These results suggest the crucial role of TIMP-3 in successful implantation and embryo survival and indicate the endometrial stromal decidualization-like in pigs.

TIMP3 Protein Überblick

Protein Überblick

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

Genbezeichner und Symbole assoziert mit TIMP3

  • metalloproteinase inhibitor 3 (CpipJ_CPIJ003282)
  • TIMP metallopeptidase inhibitor 3 (TIMP3)
  • Metalloproteinase inhibitor 3 (timp3)
  • TIMP metallopeptidase inhibitor 3 (Timp3)
  • TIMP metallopeptidase inhibitor 3 (timp3)
  • tissue inhibitor of metalloproteinase 3 (Timp3)
  • tissue inhibitor of metalloproteinase-3 (TIMP-3)
  • HSMRK222 Protein
  • IMP-3 Protein
  • K222 Protein
  • K222TA2 Protein
  • SFD Protein
  • Timp-3 Protein
  • timp3 Protein
  • timp3-A Protein

Bezeichner auf Proteinebene für TIMP3

metalloproteinase inhibitor 3 , TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor metalloproteinase-3 , TIMP metallopeptidase inhibitor 3 , Metalloproteinase inhibitor 3 , MIG-5 protein , TIMP-3 , protein MIG-5 , tissue inhibitor of metalloproteinases 3 , tissue inhibitor of metalloproteinase-3 , tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) , tissue inhibitor of metalloproteinase 3 , 21 kDa protein of extracellular matrix , tissue inhibitor of metalloproteinases-3

GENE ID SPEZIES
6034728 Culex quinquefasciatus
481289 Canis lupus familiaris
100135460 Papio anubis
100196821 Salmo salar
7078 Homo sapiens
100008690 Oryctolagus cuniculus
25358 Rattus norvegicus
282094 Bos taurus
100033947 Equus caballus
396483 Gallus gallus
373596 Xenopus laevis
574381 Macaca mulatta
100217407 Ovis aries
21859 Mus musculus
396775 Sus scrofa
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