T Cell Immunoglobulin and Mucin Domain Containing 2 Proteine (TIMD2)

Probable receptor for SEMA4A involved in the regulation of T-cell function. Zusätzlich bieten wir Ihnen TIMD2 Antikörper (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIMD2 171284 Q8R183
TIMD2 287222 Q5FVR0
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Showing 2 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.530,00 €
Details

TIMD2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
,
Rat (Rattus)

Weitere Proteine zu T Cell Immunoglobulin and Mucin Domain Containing 2 (TIMD2) Interaktionspartnern

Mouse (Murine) T Cell Immunoglobulin and Mucin Domain Containing 2 (TIMD2) Interaktionspartner

  1. We concluded that pro-apoptotic effects on Th1 (zeige HAND1 Proteine) population through galectin-9 (zeige LGALS9 Proteine)-Tim-3 (zeige HAVCR2 Proteine) pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.

  2. TIM-2 signaling influences both proliferation and antibody production of B cells during the early phase of collagen-induced arthritis

  3. TIM-2 can function as an iron uptake pathway.

  4. The increased expression of the pro-inflammatory and proapoptotic genes, a higher number of apoptotic cells, and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.

  5. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis.

  6. expression of TIM-2 significantly impairs the induction of NFAT (zeige NFATC1 Proteine) and AP-1 (zeige JUN Proteine) transcriptional reporters

  7. The mTIM-1 structure identified a homophilic TIM-TIM adhesion interaction, whereas the mTIM-2 domain formed a dimer that prevented homophilic binding.

  8. There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.

  9. Tim-2 negatively regulates the Th2 differentiation of Ag-primed T-cells and the development of EC during the effector phase.

TIMD2 Protein Überblick

Protein Überblick

Probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation (By similarity).

Genbezeichner und Symbole assoziert mit TIMD2

  • T cell immunoglobulin and mucin domain containing 2 (Timd2)
  • T-cell immunoglobulin and mucin domain containing 2 (Timd2)
  • AA816106 Protein
  • AU019358 Protein
  • AU019662 Protein
  • C78111 Protein
  • G9D3 Protein
  • TIM-2 Protein
  • Tim2 Protein

Bezeichner auf Proteinebene für TIMD2

T-cell immunoglobulin and mucin domain containing 2 , T-cell immunoglobulin and mucin domain-containing protein 2 , T-cell membrane protein 2 , TIMD-2 , TIM-2

GENE ID SPEZIES
171284 Mus musculus
287222 Rattus norvegicus
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