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SYN1 is a member of the synapsin gene family. Zusätzlich bieten wir Ihnen Synapsin I Antikörper (290) und Synapsin I Kits (28) und viele weitere Produktgruppen zu diesem Protein an.
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These findings contribute to previous work showing dysregulation of Synapsins, particularly SYN2 (zeige SYN2 Proteine), in mood disorders and improve our understanding of the regulatory mechanisms that precipitate these changes likely leading to the BD or MDD phenotype.
Cerebral malaria causes pre-synaptic excitation and eventually activation of synapsin I, leading to increased neurotransmitter release.
Patterns of the immunoreactivity with antibodies to SNAP-25 (zeige SNAP25 Proteine), synapsin-I and synaptophysin (zeige SYP Proteine) are completely appropriate to those of adult's OB on the 38-40 weeks of the prenatal development.
The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS (zeige APCDD1 Proteine) assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.
these findings suggest PRICKLE1 (zeige PRICKLE1 Proteine) mutations contribute to ASD (zeige ARSD Proteine) by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
Data indicate that in patients carrying the W356x mutation the function of synapsin I is markedly impaired, and support the value of Syn1(-/-) mice as an experimental model mimicking the human pathology.
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.
The histone modification marks were significantly increased in major depression and this effect was correlated with significant increases in SYN1b gene expression.
A conserved region of human and mouse SYN1 promoters contains cis (zeige CISH Proteine)-sites for the transcriptional activator Sp1 (zeige PSG1 Proteine) in close proximity to REST binding motifs.
The allelic frequencies of SYN1 are associated with Korean female schizophrenia.
This study demonstrated that syn1 affect the rate of release of GABA quanta residing within the Hippocampal Interneurons.
Synapsin I is localized and produced at mature axon terminals and at immature growth cones.
HSV-1-infected neurons also exhibite significantly reduced expression of the presynaptic proteins synapsin-1 and synaptophysin. These effects depended on GSK-3 activation and intraneuronal accumulation of Ab
Functions of synapsins in corticothalamic facilitation: important roles of synapsin I
SynI mRNA and protein levels are down-regulated in the hippocampus of naive and Morris water maze-treated En2 (zeige EN2 Proteine)-/- mice.
these findings suggest PRICKLE1 (zeige PRICKLE1 Proteine) mutations contribute to ASD (zeige GUSB Proteine) by disrupting the interaction with SYN1 and regulation of synaptic vesicles.
during chronic modification of neuronal activity and is an essential downstream effector for the Cdk5 (zeige CDK5 Proteine)-mediated homeostatic scaling.
O-GlcNAcylation of Thr (zeige TRH Proteine)-87 interferes with folding of the ALPS motif, providing a means for regulating the association of synapsin I with SVs (zeige FGFR2 Proteine) as a mechanism contributing to synapsin I localization and RPSV generation.
These results raise the possibility that Ser (zeige SIGLEC1 Proteine)(603) on synapsin I is alternatively phosphorylated by p21 (zeige CDKN1A Proteine)-activated kinases, not only by CaMKII (zeige CAMK2G Proteine), in neuronal cells in response to some stimulants.
Synapsin-Rab3 (zeige RAB3A Proteine) interaction may participate in the regulation of synaptic vesicle trafficking within the nerve terminals.
Interacts with rab3 (zeige RAB3A Proteine) protein; this interaction is likely to play a major role in the modulation of neurotransmitter release.
This study reports molecular cloning and characterization of the coding sequence of the porcine ortholog of syn (zeige SYNM Proteine) I, including identification and verification at the protein level of an alanine-encoding insert.
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
, synapsin 1
, brain protein 4.1