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SYMPK encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. Zusätzlich bieten wir Ihnen Symplekin Antikörper (53) und Symplekin Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Authors propose a model in which the core cleavage complex formation is mediated by CPSF73 (zeige CPSF3 Proteine), CPSF100 (zeige CPSF2 Proteine), and Symplekin C-termini, and the N-terminal region of Symplekin facilitates cotranscriptional 3' end processing of histone mRNAs.
This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 (zeige CPSF3 Proteine) and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions.
Together, these data support the conclusion that the Symplekin HEAT domain serves as a scaffold for protein-protein interactions essential to the mRNA maturation process.
Data indicate rs56848936 in the gene symplekin protein (SYMPK) at 19q13.3, associated with colon cancer risk.
CPSF2 (zeige CPSF2 Proteine) and SYMPK, are RBFOX2 (zeige RBM9 Proteine) cofactors for both inclusion and exclusion of internal exons.
Symplekin interacts and co-localizes with both MOZ and MLL (zeige MLL Proteine) in immature hematopoietic cells. Its inhibition leads to a decrease of the HOXA9 (zeige HOXA9 Proteine) protein level but not of Hoxa9 (zeige HOXA9 Proteine) mRNA.
Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser (zeige SIGLEC1 Proteine) 5 phosphatase Ssu72 (zeige SSU72 Proteine) and a CTD Ser (zeige SIGLEC1 Proteine) 5 phosphopeptide
Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp).
Data show that claudin-2 (zeige CLDN2 Proteine) expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 (zeige CLDN2 Proteine) down-regulation increased the transepithelial resistance and decreased cyclin D1 (zeige CCND1 Proteine) expression and ZONAB (zeige CSDA Proteine) nuclear localization.
symplekin has a role in HSF1 (zeige HSF1 Proteine) modulation of Hsp70 (zeige HSP70 Proteine) mRNA polyadenylation
The decreased expression of symplekin may be an early step in the transformation of hepatocytes, whereas alteration of the expression of adherens junctions and desmosomes may indicate more serious changes.
The symplekin/ZONAB (zeige CSDA Proteine) complex inhibits intestinal cell differentiation by the repression of AML1/Runx1 (zeige RUNX1 Proteine).
Here, we identify a new factor essential for polyadenylation, namely, symplekin, a CPEB and CPSF (zeige CPSF2 Proteine) binding protein that serves as a scaffold upon which regulatory factors are assembled
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types.
, hepatocyte nuclear factor 3 gamma