Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteine (SUV39H1)

SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Zusätzlich bieten wir Ihnen Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Antikörper (97) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SUV39H1 6839 O43463
SUV39H1 20937 O54864
Ratte SUV39H1 SUV39H1 302553  
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Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,144.17
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Hefe Pongo abelii His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,144.17
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,173.50
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Escherichia coli (E. coli) Human GST tag SUV39H1 activity assay. Recombinant SUV39H1 activity measured using a fluorescent histone H3 lysine 9 methyltransferase assay. SUV39H1 protein gel. SUV39H1 (4.2 μg) run on a 10% SDS-PAGE gel and stained with Coomassie blue. Arrow indicates recombinant SUV39H1. 25 μg Anmelden zum Anzeigen 1 bis 2 Tage
$466.67
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SUV39H1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaktionspartnern

Human Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaktionspartner

  1. Overexpression of miR (zeige MLXIP Proteine)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.

  2. KAT7 (zeige MYST2 Proteine)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.

  3. Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (zeige CBX5 Proteine) and gamma, and enhances HP1beta (zeige CBX1 Proteine) levels.

  4. we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1

  5. These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.

  6. CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (zeige DEFA1 Proteine)/DNMT3A (zeige DNMT3A Proteine) in DNA methylation (zeige HELLS Proteine)-based epigenetic silencing

  7. PHF2 (zeige PHF1 Proteine) is likely to repress rDNA transcription by competing with PHF8 (zeige PHF8 Proteine) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.

  8. High SUV39H1 expression is associated with hepatocellular carcinoma.

  9. Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (zeige BCL2 Proteine), pro-caspase-9 (zeige CASP9 Proteine), pro-caspase-3 (zeige CASP3 Proteine) and C-myc (zeige MYC Proteine). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.

  10. SUV39H1 expression was upregulated in glioma cell lines and in glioma tissues compared to normal brain, being positively correlated with grade and histological malignancy.

Mouse (Murine) Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaktionspartner

  1. Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin (zeige FN1 Proteine) and p21(WAF1 (zeige CDKN1A Proteine)) in mesangial cells

  2. Overexpression of miR (zeige MLXIP Proteine)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.

  3. Activation of p38alpha (zeige MAPK14 Proteine) displaces KMT1A from MyoD (zeige MYOD1 Proteine) to initiate myogenic gene expression upon induction of myoblasts differentiation.

  4. Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (zeige CBX5 Proteine) to the promoter of the ancestral Oct4 (zeige POU5F1 Proteine) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.

  5. Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.

  6. Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.

  7. These findings indicate that Suv39h1 enhances AP-2alpha (zeige TFAP2A Proteine)-mediated transcriptional repression of C/EBPalpha (zeige CEBPA Proteine) in an epigenetic manner and further inhibits adipocyte differentiation.

  8. A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.

  9. Data indicate that loss of suv39h1 prevents Myc (zeige MYC Proteine)-induced chromosomal instability.

  10. Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (zeige IL2 Proteine) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (zeige IL2 Proteine) transcription.

Zebrafish Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Interaktionspartner

  1. The identification of a histone H3 (zeige HIST3H3 Proteine) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.

  2. These results suggest that Dnmt1 (zeige DNMT1 Proteine) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (zeige DNMT1 Proteine) and Suv39h1 help guide the terminal differentiation of particular tissues.

Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1) Protein Überblick

Protein Überblick

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

Genbezeichner und Symbole assoziert mit SUV39H1

  • suppressor of variegation 3-9 homolog 1 L homeolog (suv39h1.L)
  • suppressor of variegation 3-9 homolog 1 (SUV39H1)
  • suppressor of variegation 3-9 homolog 1 (Drosophila) (Suv39h1)
  • suppressor of variegation 3-9 homolog 1a (suv39h1a)
  • AI852103 Protein
  • AL022883 Protein
  • DXHXS7466e Protein
  • fe02c04 Protein
  • H3-K9-HMTase 1 Protein
  • KMT1A Protein
  • MG44 Protein
  • mIS6 Protein
  • RGD1565028 Protein
  • SUV39H Protein
  • suv39h1 Protein
  • wu:fe02c04 Protein
  • zgc:101027 Protein

Bezeichner auf Proteinebene für SUV39H1

histone-lysine N-methyltransferase SUV39H1 , su(var)3-9 homolog 1 , Su(var)3-9 homolog 1 , histone H3-K9 methyltransferase 1 , histone-lysine N-methyltransferase, H3 lysine-9 specific 1 , lysine N-methyltransferase 1A , position-effect variegation 3-9 homolog , H3-K9-HMTase 1 , Suv39h histone methyltransferase , histone-lysine N-methyltransferase SUV39H1-A , su(var)3-9 homolog 1-A , suppressor of variegation 3-9 homolog 1 , suppressor of variegation 3-9 homolog 1-A , suppressor of variegation 3-9-like 1a

GENE ID SPEZIES
431943 Xenopus laevis
6839 Homo sapiens
491868 Canis lupus familiaris
523047 Bos taurus
20937 Mus musculus
302553 Rattus norvegicus
100172621 Pongo abelii
445198 Danio rerio
Ausgewählte Anbieter für Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Proteine (SUV39H1)
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