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SUV39H1 is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. Zusätzlich bieten wir Ihnen Suppressor of Variegation 3-9 Homolog 1 (Drosophila) Antikörper (97) und viele weitere Produktgruppen zu diesem Protein an.
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Our data show that the differential expression of SUV39H1 and SUV39H2 (zeige SUV39H2 Proteine) is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution
Overexpression of miR (zeige MLXIP Proteine)-125b and inhibition of its target, SUV39H1, in aging individuals reduces hematopoietic stem cells capacity of B cells generation.
KAT7 (zeige MYST2 Proteine)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres.
Suv39h1 deficiency abrogates stress-dependent upregulation of HP1alpha (zeige CBX5 Proteine) and gamma, and enhances HP1beta (zeige CBX1 Proteine) levels.
we describe the synthesis of multidomain 'designer chromatin' templates and their application to dissecting the regulation of human Suv39h1
These results suggest a model in which SUV39H1 downregulation promotes the establishment of cellular senescence.
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1 (zeige DEFA1 Proteine)/DNMT3A (zeige DNMT3A Proteine) in DNA methylation (zeige HELLS Proteine)-based epigenetic silencing
PHF2 (zeige PHF1 Proteine) is likely to repress rDNA transcription by competing with PHF8 (zeige PHF8 Proteine) for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1.
High SUV39H1 expression is associated with hepatocellular carcinoma.
Suv39H1 induced apoptosis and inhibited cell proliferation in the gastric cancer MGC803 cell line, while decreasing BCL-2 (zeige BCL2 Proteine), pro-caspase-9 (zeige CASP9 Proteine), pro-caspase-3 (zeige CASP3 Proteine) and C-myc (zeige MYC Proteine). Suv39H1 may be a potential gene target for anti-gastric carcinoma therapy.
Histone methyltransferase Suv39h1 attenuates high glucose-induced fibronectin (zeige FN1 Proteine) and p21(WAF1 (zeige CDKN1A Proteine)) in mesangial cells
Activation of p38alpha (zeige MAPK14 Proteine) displaces KMT1A from MyoD (zeige MYOD1 Proteine) to initiate myogenic gene expression upon induction of myoblasts differentiation.
Oct4P4 lncRNA forms a complex with the SUV39H1 HMTase to direct the imposition of H3K9me3 and HP1alpha (zeige CBX5 Proteine) to the promoter of the ancestral Oct4 (zeige POU5F1 Proteine) gene, located on chromosome 17, leading to gene silencing and reduced mESC self-renewal.
Provide genetic evidence that Suv39h1 controls telomere homeostasis and mediates resistance to oncogenic stress in vivo, conferring resistance to skin carcinogenesis.
Repeat-associated, Suv39h-dependent H3K9me3 displays a dynamic distribution that differs in the epigenome of pluripotent versus more committed cells.
These findings indicate that Suv39h1 enhances AP-2alpha (zeige TFAP2A Proteine)-mediated transcriptional repression of C/EBPalpha (zeige CEBPA Proteine) in an epigenetic manner and further inhibits adipocyte differentiation.
A-type lamins interact with SUV39H1, and prelamin A/progerin exhibits enhanced binding capacity to SUV39H1, protecting it from proteasomal degradation and, consequently, increasing H3K9me3 levels.
Data indicate that loss of suv39h1 prevents Myc (zeige MYC Proteine)-induced chromosomal instability.
Smads recruit H3K9 methyltransferases Suv39h1 to the IL-2 (zeige IL2 Proteine) promoter, thereby inducing suppressive histone methylation and inhibiting T cell receptor-mediated IL-2 (zeige IL2 Proteine) transcription.
The identification of a histone H3 (zeige HIST3H3 Proteine) lysine 9 histone methyltransferase, SUV39H1, as a suppressor of embryonal rhabdomyosarcoma formation in zebrafish, is described.
These results suggest that Dnmt1 (zeige DNMT1 Proteine) activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 (zeige DNMT1 Proteine) and Suv39h1 help guide the terminal differentiation of particular tissues.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
histone-lysine N-methyltransferase SUV39H1
, su(var)3-9 homolog 1
, Su(var)3-9 homolog 1
, histone H3-K9 methyltransferase 1
, histone-lysine N-methyltransferase, H3 lysine-9 specific 1
, lysine N-methyltransferase 1A
, position-effect variegation 3-9 homolog
, H3-K9-HMTase 1
, Suv39h histone methyltransferase
, histone-lysine N-methyltransferase SUV39H1-A
, su(var)3-9 homolog 1-A
, suppressor of variegation 3-9 homolog 1
, suppressor of variegation 3-9 homolog 1-A
, suppressor of variegation 3-9-like 1a